trans-2-<<2-(1H-indol-3-yl)ethyl>amino>-cis-5-phenoxycyclopentanol

Base Information

• Chemical Name: trans-2-<<2-(1H-indol-3-yl)ethyl>amino>-cis-5-phenoxycyclopentanol
• CAS No.: 97133-68-1
• Molecular Formula: C₂₁H₂₄N₂O₂
• Molecular Weight: 336.434
• Mol file: 97133-68-1.mol

Synonyms:

Chemical Property of trans-2-<<2-(1H-indol-3-yl)ethyl>amino>-cis-5-phenoxycyclopentanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-2-<<2-(1H-indol-3-yl)ethyl>amino>-cis-5-phenoxycyclopentanol

There total 6 articles about trans-2-<<2-(1H-indol-3-yl)ethyl>amino>-cis-5-phenoxycyclopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclopent-2-enol (3212-60-0,6426-28-4,62894-08-0,109431-72-3) → trans-2-<<2-(1H-indol-3-yl)ethyl>amino>-cis-5-phenoxycyclopentanol (97133-68-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 57 percent / vanadyl acetylacetonate, tert-butyl hydroperoxide / benzene / 1.) 80 deg C, 15 min, 2.) 40 deg C, 5 h

2: 85 percent / KH / tetrahydrofuran / 45 °C

3: 1.25 g / ethanol / 72 h / Heating

With tert.-butylhydroperoxide; vanadyl acetylacetonate; potassium hydride; In tetrahydrofuran; ethanol; benzene;

DOI:10.1021/jo00217a017

Reference yield:

1-phenoxy-2-cyclopentene (95526-36-6) → trans-2-<<2-(1H-indol-3-yl)ethyl>amino>-cis-5-phenoxycyclopentanol (97133-68-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 17.7 percent / 3-chloroperbenzoic acid (MCBA) / CH₂Cl₂ / 15 h / 4 - 20 °C

2: 1.25 g / ethanol / 72 h / Heating

With 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane;

DOI:10.1021/jo00217a017

Reference yield:

cis-6-oxabicyclo<3.1.0>cyclohexan-2-ol (25484-62-2,29782-88-5,765-54-8,25516-47-6,34310-95-7,120577-03-9,139015-06-8) → trans-2-<<2-(1H-indol-3-yl)ethyl>amino>-cis-5-phenoxycyclopentanol (97133-68-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / KH / tetrahydrofuran / 45 °C

2: 1.25 g / ethanol / 72 h / Heating

With potassium hydride; In tetrahydrofuran; ethanol;

DOI:10.1021/jo00217a017

upstream raw materials:

tryptamine

cis-2-phenoxy-6-oxabicyclo<3.1.0>hexane

cyclopent-2-enol

1-phenoxy-2-cyclopentene