11-Benzyloxymethyl-13-hydroxy-5,8,9,10,11,12,13,14-octahydro-6H-7,14-diaza-cycloundeca[a]indene-7-carboxylic acid benzyl ester

Base Information

• Chemical Name: 11-Benzyloxymethyl-13-hydroxy-5,8,9,10,11,12,13,14-octahydro-6H-7,14-diaza-cycloundeca[a]indene-7-carboxylic acid benzyl ester
• CAS No.: 107688-24-4
• Molecular Formula: C₃₂H₃₆N₂O₄
• Molecular Weight: 512.649
• Mol file: 107688-24-4.mol

Synonyms:

Chemical Property of 11-Benzyloxymethyl-13-hydroxy-5,8,9,10,11,12,13,14-octahydro-6H-7,14-diaza-cycloundeca[a]indene-7-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11-Benzyloxymethyl-13-hydroxy-5,8,9,10,11,12,13,14-octahydro-6H-7,14-diaza-cycloundeca[a]indene-7-carboxylic acid benzyl ester

There total 6 articles about 11-Benzyloxymethyl-13-hydroxy-5,8,9,10,11,12,13,14-octahydro-6H-7,14-diaza-cycloundeca[a]indene-7-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + 2-benzyloxymethyl-2,3,4,5,6,7,8,13,13b-octahydro-1H-azepino<1',2':1,2>pyrido<3,4-b>indol (107688-23-3) → 3-benzyloxycarbonyl-7-benzyloxymethyl-9-hydroxy-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol (107688-24-4,116260-72-1,116260-77-6) + 3-benzyloxycarbonyl-7-benzyloxymethyl-9-hydroxy-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol (107688-24-4,116260-72-1,116260-77-6)

Guidance literature:

With sodium carbonate; In tetrahydrofuran; at 50 ℃; for 16h; Yield given. Yields of byproduct given;

DOI:10.1016/S0040-4020(01)86863-0

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + 2-benzyloxymethyl-2,3,4,5,6,7,8,13,13b-octahydro-1H-azepino<1',2':1,2>pyrido<3,4-b>indol (107688-23-3) → 3-benzyloxycarbonyl-7-benzyloxymethyl-9-hydroxy-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol (107688-24-4,116260-72-1,116260-77-6) + 3-benzyloxycarbonyl-7-benzyloxymethyl-9-hydroxy-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol (107688-24-4,116260-72-1,116260-77-6)

Guidance literature:

With sodium carbonate; In tetrahydrofuran; at 50 ℃; for 16h; Yield given. Yields of byproduct given;

DOI:10.1016/S0040-4020(01)86863-0

Reference yield:

tryptamine (61-54-1) → 11-Benzyloxymethyl-13-hydroxy-5,8,9,10,11,12,13,14-octahydro-6H-7,14-diaza-cycloundeca[a]indene-7-carboxylic acid benzyl ester (116260-72-1,116260-77-6,107688-24-4)

Guidance literature:

Multi-step reaction with 3 steps

2: LiAlH₄

3: H₂O / tetrahydrofuran

With lithium aluminium tetrahydride; water; In tetrahydrofuran;

DOI:10.1002/hlca.19860690225

upstream raw materials:

benzyl chloroformate

2-benzyloxymethyl-2,3,4,5,6,7,8,13,13b-octahydro-1H-azepino<1',2':1,2>pyrido<3,4-b>indol

tryptamine

4-benzyloxymethyl-6-oxocapronsauremethylester

Downstream raw materials:

3-benzyloxycarbonyl-7-methansulfonyloxymethyl-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-9-carbonsauremethylester

3-benzyloxycarbonyl-7-benzyloxymethyl-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-9-carbonsauremethylester

3-benzyloxycarbonyl-7-benzyloxymethyl-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-7-carbonsaureamid

3-benzyloxycarbonyl-7-benzyloxymethyl-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-9-carbonsaurenitril