Technology Process of (3S,3aR,5S,7S,7aS)-3-Benzyloxy-5-isobutoxy-7-triisopropylsilanyloxymethyl-octahydro-pyrano[3,4-b]pyrrole
There total 12 articles about (3S,3aR,5S,7S,7aS)-3-Benzyloxy-5-isobutoxy-7-triisopropylsilanyloxymethyl-octahydro-pyrano[3,4-b]pyrrole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 2,6-lutidine / -5 °C
2: 96 percent / (COCl)2; DMSO; Et3N / -78 °C
3: 96 percent / I2; pyridine / CH2Cl2
4: 67 percent / NaBH4; CeCl3*7H2O / methanol
5: 57 percent / DIAD; PPh3 / tetrahydrofuran / 20 °C
6: 72 percent / n-BuLi / tetrahydrofuran / -78 °C
7: 96 percent / NaBH4; CeCl3*7H2O / methanol
8: 78 percent / (PPh3)3RhCl; H2
9: 92 percent / NaH / tetrahydrofuran
10: 90 percent / Na; naphthalene
With
pyridine; 2,6-dimethylpyridine; sodium tetrahydroborate; Wilkinson's catalyst; n-butyllithium; cerium(III) chloride; oxalyl dichloride; naphthalene; di-isopropyl azodicarboxylate; hydrogen; iodine; sodium; sodium hydride; dimethyl sulfoxide; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane;
2: Swern oxidation / 4: Luche reduction / 5: Mitsunobu reaction / 7: Luche reduction;
DOI:10.1016/j.bmcl.2005.08.062
- Guidance literature:
-
Multi-step reaction with 11 steps
1: K2CO3; MeOH
2: 2,6-lutidine / -5 °C
3: 96 percent / (COCl)2; DMSO; Et3N / -78 °C
4: 96 percent / I2; pyridine / CH2Cl2
5: 67 percent / NaBH4; CeCl3*7H2O / methanol
6: 57 percent / DIAD; PPh3 / tetrahydrofuran / 20 °C
7: 72 percent / n-BuLi / tetrahydrofuran / -78 °C
8: 96 percent / NaBH4; CeCl3*7H2O / methanol
9: 78 percent / (PPh3)3RhCl; H2
10: 92 percent / NaH / tetrahydrofuran
11: 90 percent / Na; naphthalene
With
pyridine; 2,6-dimethylpyridine; methanol; sodium tetrahydroborate; Wilkinson's catalyst; n-butyllithium; cerium(III) chloride; oxalyl dichloride; naphthalene; di-isopropyl azodicarboxylate; hydrogen; iodine; sodium; sodium hydride; potassium carbonate; dimethyl sulfoxide; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane;
3: Swern oxidation / 5: Luche reduction / 6: Mitsunobu reaction / 8: Luche reduction;
DOI:10.1016/j.bmcl.2005.08.062
![(3S,3aR,5S,7S,7aS)-3-Benzyloxy-5-isobutoxy-1-(toluene-4-sulfonyl)-7-triisopropylsilanyloxymethyl-octahydro-pyrano[3,4-b]pyrrole](/Databaselist/images/loading.webp)
