(S)-2,2,2-trifluoro-N-(1-(2-(methyl)phenyl)ethyl)acetamide

Base Information

Chemical Name:(S)-2,2,2-trifluoro-N-(1-(2-(methyl)phenyl)ethyl)acetamide
CAS No.:1332827-98-1
Molecular Formula:C₁₁H₁₂F₃NO
Molecular Weight:231.218
Hs Code.:

Synonyms:

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Chemical Property of (S)-2,2,2-trifluoro-N-(1-(2-(methyl)phenyl)ethyl)acetamide

Chemical Property:

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Technology Process of (S)-2,2,2-trifluoro-N-(1-(2-(methyl)phenyl)ethyl)acetamide

There total 17 articles about (S)-2,2,2-trifluoro-N-(1-(2-(methyl)phenyl)ethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 577-16-2,122382-54-1
2-Methylacetophenone

: 1332827-98-1
(S)-2,2,2-trifluoro-N-(1-(2-(methyl)phenyl)ethyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: titanium(IV) isopropylate / Isopropyl acetate / 0.5 h

2: 5%-palladium/activated carbon; hydrogen / Isopropyl acetate / 24 h / 24 °C / 11251.1 Torr

3: 5%-palladium/activated carbon; hydrogen / Isopropyl acetate / 24 h / 55 °C

4: hydrogenchloride / dichloromethane; water

5: sodium hydroxide / dichloromethane; water

6: tetrahydrofuran / 0.5 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; 5%-palladium/activated carbon; hydrogen; sodium hydroxide; In tetrahydrofuran; dichloromethane; Isopropyl acetate; water;
DOI:10.1002/adsc.201100250

Reference yield:

: C₁₇H₁₉N

: 1332827-98-1
(S)-2,2,2-trifluoro-N-(1-(2-(methyl)phenyl)ethyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: Pd/Al₂O₃; hydrogen / Isopropyl acetate / 24 h / 35 °C / 11251.1 Torr

2: 5%-palladium/activated carbon; hydrogen / methanol / 24 h / 60 °C / 11251.1 Torr

3: tetrahydrofuran / 0.5 h / 20 °C

With Pd/Al₂O₃; 5%-palladium/activated carbon; hydrogen; In tetrahydrofuran; methanol; Isopropyl acetate;
DOI:10.1002/adsc.201100250

Reference yield:

: N-[(S)-1-(2-methylphenyl)ethyl]-1-phenylethanamine

: 1332827-98-1
(S)-2,2,2-trifluoro-N-(1-(2-(methyl)phenyl)ethyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: isopropyl alcohol / 78 °C

2: sodium hydroxide / water; ethyl acetate

3: 5%-palladium/activated carbon; hydrogen / methanol / 24 h / 60 °C / 11251.1 Torr

4: tetrahydrofuran / 0.5 h / 20 °C

With 5%-palladium/activated carbon; hydrogen; sodium hydroxide; In tetrahydrofuran; methanol; water; ethyl acetate; isopropyl alcohol;
DOI:10.1002/adsc.201100250