benzyl (R)-2-benzyl-3-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-oxopropylcarbamate

Base Information

Chemical Name:benzyl (R)-2-benzyl-3-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-oxopropylcarbamate
CAS No.:1391826-39-3
Molecular Formula:C₂₈H₂₈N₂O₅
Molecular Weight:472.541
Hs Code.:

Synonyms:

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Chemical Property of benzyl (R)-2-benzyl-3-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-oxopropylcarbamate

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Technology Process of benzyl (R)-2-benzyl-3-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-oxopropylcarbamate

There total 4 articles about benzyl (R)-2-benzyl-3-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-oxopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 94471-35-9
benzyl N-(methoxymethyl) carbamate

: 136159-65-4,96930-27-7
(S)-4-benzyl-3-(3-phenylpropanoyl)oxazolidin-2-one

: 1391826-39-3
benzyl (R)-2-benzyl-3-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-oxopropylcarbamate

Guidance literature:: (S)-4-benzyl-3-(3-phenylpropanoyl)oxazolidin-2-one; With titanium tetrachloride; triethylamine; In dichloromethane; at -20 ℃; for 0.5h; Inert atmosphere;

benzyl N-(methoxymethyl) carbamate; With titanium tetrachloride; In dichloromethane; at 0 ℃; for 3h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/chem.201200313

Reference yield:

: 31037-42-0
hydroxymethyl carbamic acid benzyl ester

: 1391826-39-3
benzyl (R)-2-benzyl-3-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-oxopropylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / diethyl ether / 1 h / 20 °C / Inert atmosphere; Molecular sieve

2.1: titanium tetrachloride; triethylamine / dichloromethane / 0.5 h / -20 °C / Inert atmosphere

2.2: 3 h / 0 °C / Inert atmosphere

With titanium tetrachloride; toluene-4-sulfonic acid; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1002/chem.201200313

Reference yield:

: 645-45-4
hydrocinnamic acid chloride

: 1391826-39-3
benzyl (R)-2-benzyl-3-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-oxopropylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: 18 h / -78 - 20 °C / Inert atmosphere

2.1: titanium tetrachloride; triethylamine / dichloromethane / 0.5 h / -20 °C / Inert atmosphere

2.2: 3 h / 0 °C / Inert atmosphere

With n-butyllithium; titanium tetrachloride; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/chem.201200313