C₂₄H₂₂Cl₂F₃N₃O₃

Base Information

• Chemical Name: C₂₄H₂₂Cl₂F₃N₃O₃
• CAS No.: 1622386-83-7
• Molecular Formula: C₂₄H₂₂Cl₂F₃N₃O₃
• Molecular Weight: 528.358
• Mol file: 1622386-83-7.mol

Synonyms:

Chemical Property of C₂₄H₂₂Cl₂F₃N₃O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₂Cl₂F₃N₃O₃

There total 4 articles about C₂₄H₂₂Cl₂F₃N₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-difluoro-6-morpholinobenzonitrile (1622386-79-1) → C24H22Cl2F3N3O3 (1622386-83-7)

Guidance literature:

Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; potassium carbonate / dimethyl sulfoxide / 20 °C

2: acetic acid / 0.5 h / 20 °C

3: 5%-palladium/activated carbon; hydrogen / 2.5 h / 1520.1 Torr

4: sodium acetate / ethanol / 20 h / Reflux

With 5%-palladium/activated carbon; hydroxylamine hydrochloride; hydrogen; sodium acetate; potassium carbonate; acetic acid; In ethanol; dimethyl sulfoxide; 4: |Biginelli Pyrimidone Synthesis;

DOI:10.1016/j.bmcl.2014.07.032

Reference yield:

C11H13F2N3O2 (1622386-80-4) → C24H22Cl2F3N3O3 (1622386-83-7)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 0.5 h / 20 °C

2: 5%-palladium/activated carbon; hydrogen / 2.5 h / 1520.1 Torr

3: sodium acetate / ethanol / 20 h / Reflux

With 5%-palladium/activated carbon; hydrogen; sodium acetate; acetic acid; In ethanol; 3: |Biginelli Pyrimidone Synthesis;

DOI:10.1016/j.bmcl.2014.07.032

Reference yield:

C13H15F2N3O3 → C24H22Cl2F3N3O3 (1622386-83-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 5%-palladium/activated carbon; hydrogen / 2.5 h / 1520.1 Torr

2: sodium acetate / ethanol / 20 h / Reflux

With 5%-palladium/activated carbon; hydrogen; sodium acetate; In ethanol; 2: |Biginelli Pyrimidone Synthesis;

DOI:10.1016/j.bmcl.2014.07.032

upstream raw materials:

2,4-difluoro-6-morpholinobenzonitrile

C₁₁H₁₃F₂N₃O₂

ethyl (2-chloroaceto)acetate

C₁₁H₁₃F₂N₃O*C₂H₄O₂

Downstream raw materials:

ethyl 2-[2,4-difluoro-6-(morpholin-4-yl)phenyl]-4-(2-chlor-4-fluorophenyl)-6-(morpholine-4-ylmethyl)-1,4-dihydropyrimidine-5-carboxylate