C₂₉H₃₄F₂N₈O₂

Base Information

• Chemical Name: C₂₉H₃₄F₂N₈O₂
• CAS No.: 1300100-44-0
• Molecular Formula: C₂₉H₃₄F₂N₈O₂
• Molecular Weight: 564.638
• Mol file: 1300100-44-0.mol

Synonyms:

Chemical Property of C₂₉H₃₄F₂N₈O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₉H₃₄F₂N₈O₂

There total 5 articles about C₂₉H₃₄F₂N₈O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-2-oxoazepan-3-yl]carbamate (781650-32-6) → C29H34F2N8O2 (1300100-44-0)

Guidance literature:

Multi-step reaction with 5 steps

1: Lawessons reagent / 90 °C

2: mercury dichloride / ethanol / 55 °C

3: dipyridinium dichromate / acetonitrile

4: trifluoroacetic acid / dichloromethane

5: triethylamine

With Lawessons reagent; dipyridinium dichromate; triethylamine; trifluoroacetic acid; mercury dichloride; In ethanol; dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2010.12.054

Reference yield:

tert-butyl (3R,6S)-6-(2,3-difluorophenyl)-2-thioxoazepan-3-ylcarbamate (880144-46-7) → C29H34F2N8O2 (1300100-44-0)

Guidance literature:

Multi-step reaction with 4 steps

1: mercury dichloride / ethanol / 55 °C

2: dipyridinium dichromate / acetonitrile

3: trifluoroacetic acid / dichloromethane

4: triethylamine

With dipyridinium dichromate; triethylamine; trifluoroacetic acid; mercury dichloride; In ethanol; dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2010.12.054

Reference yield:

C22H34F2N4O3 (1300100-66-6) → C29H34F2N8O2 (1300100-44-0)

Guidance literature:

Multi-step reaction with 3 steps

1: dipyridinium dichromate / acetonitrile

2: trifluoroacetic acid / dichloromethane

3: triethylamine

With dipyridinium dichromate; triethylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2010.12.054

upstream raw materials:

1-(piperidin-4-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

4-Nitrophenyl chloroformate

tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-2-oxoazepan-3-yl]carbamate

tert-butyl (3R,6S)-6-(2,3-difluorophenyl)-2-thioxoazepan-3-ylcarbamate