(S)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-5-guanidino-pentanoylamino]-4-methyl-pentanoic acid ((S)-1-{1-[((S)-1-carbamoyl-ethylcarbamoyl)-methyl]-5-oxo-pyrrolidin-3-ylcarbamoyl}-2-phenyl-ethyl)-amide

Base Information

• Chemical Name: (S)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-5-guanidino-pentanoylamino]-4-methyl-pentanoic acid ((S)-1-{1-[((S)-1-carbamoyl-ethylcarbamoyl)-methyl]-5-oxo-pyrrolidin-3-ylcarbamoyl}-2-phenyl-ethyl)-amide
• CAS No.: 132757-21-2
• Molecular Formula: C₃₃H₅₃N₁₁O₈
• Molecular Weight: 731.853
• Mol file: 132757-21-2.mol

Synonyms:

Chemical Property of (S)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-5-guanidino-pentanoylamino]-4-methyl-pentanoic acid ((S)-1-{1-[((S)-1-carbamoyl-ethylcarbamoyl)-methyl]-5-oxo-pyrrolidin-3-ylcarbamoyl}-2-phenyl-ethyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-5-guanidino-pentanoylamino]-4-methyl-pentanoic acid ((S)-1-{1-[((S)-1-carbamoyl-ethylcarbamoyl)-methyl]-5-oxo-pyrrolidin-3-ylcarbamoyl}-2-phenyl-ethyl)-amide

There total 2 articles about (S)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-5-guanidino-pentanoylamino]-4-methyl-pentanoic acid ((S)-1-{1-[((S)-1-carbamoyl-ethylcarbamoyl)-methyl]-5-oxo-pyrrolidin-3-ylcarbamoyl}-2-phenyl-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[2-tert-Butoxycarbonylamino-3-(ethoxycarbonylmethyl-carbamoyl)-propyl]-dimethyl-sulfonium; iodide (136101-09-2) → (S)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-5-guanidino-pentanoylamino]-4-methyl-pentanoic acid ((S)-1-{1-[((S)-1-carbamoyl-ethylcarbamoyl)-methyl]-5-oxo-pyrrolidin-3-ylcarbamoyl}-2-phenyl-ethyl)-amide (132757-21-2,132831-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / NaH

2: solid phase peptide synthesis

With sodium hydride;

DOI:10.1016/S0040-4039(00)98031-6

Reference yield:

(R,S)-3-<<(1,1-Dimethylethoxy)carbonyl>amino>-5-oxo-1-pyrrolidine acetic acid (132757-20-1) → (S)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-5-guanidino-pentanoylamino]-4-methyl-pentanoic acid ((S)-1-{1-[((S)-1-carbamoyl-ethylcarbamoyl)-methyl]-5-oxo-pyrrolidin-3-ylcarbamoyl}-2-phenyl-ethyl)-amide (132757-21-2,132831-72-2)

Guidance literature:

solid phase peptide synthesis;

DOI:10.1016/S0040-4039(00)98031-6

upstream raw materials:

(R,S)-3-<<(1,1-Dimethylethoxy)carbonyl>amino>-5-oxo-1-pyrrolidine acetic acid

[2-tert-Butoxycarbonylamino-3-(ethoxycarbonylmethyl-carbamoyl)-propyl]-dimethyl-sulfonium; iodide