3-<(2-aminoethyl)thio>-1-benzylindole

Base Information

Chemical Name:3-<(2-aminoethyl)thio>-1-benzylindole
CAS No.:61021-77-0
Molecular Formula:C₁₇H₁₈N₂S
Molecular Weight:282.409
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-<(2-aminoethyl)thio>-1-benzylindole

Chemical Property:

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Technology Process of 3-<(2-aminoethyl)thio>-1-benzylindole

There total 4 articles about 3-<(2-aminoethyl)thio>-1-benzylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61021-40-7
(1-Benzyl-1H-indol-3-ylsulfanyl)-acetonitrile

: 61021-77-0
3-<(2-aminoethyl)thio>-1-benzylindole

Guidance literature:: With boron trifluoride-tetrahydrofuran complex; In tetrahydrofuran; for 18h; Ambient temperature;
DOI:10.1021/jm00356a021

Reference yield:

: 120-72-9
indole

: 61021-77-0
3-<(2-aminoethyl)thio>-1-benzylindole

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) thiourea, I₂, KI, 2.) 1.5 N aq. NaOH / 1.) MeOH, RT, 2 h, 2.) MeOH, 90 deg C, 30 min

2: NaOH / methanol; H₂O; diethyl ether / 2 h / Ambient temperature

3: 50percent aq. NaOH, benzyltriethylammonium chloride / diethyl ether / Ambient temperature

4: 1 M BF₃*THF / tetrahydrofuran / 18 h / Ambient temperature

With sodium hydroxide; boron trifluoride-tetrahydrofuran complex; N-benzyl-N,N,N-triethylammonium chloride; iodine; thiourea; potassium iodide; In tetrahydrofuran; methanol; diethyl ether; water;
DOI:10.1021/jm00356a021

Reference yield:

: 61021-51-0
2-((1H-indol-3-yl)thio)acetonitrile

: 61021-77-0
3-<(2-aminoethyl)thio>-1-benzylindole

Guidance literature:: Multi-step reaction with 2 steps

1: 50percent aq. NaOH, benzyltriethylammonium chloride / diethyl ether / Ambient temperature

2: 1 M BF₃*THF / tetrahydrofuran / 18 h / Ambient temperature

With sodium hydroxide; boron trifluoride-tetrahydrofuran complex; N-benzyl-N,N,N-triethylammonium chloride; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jm00356a021