C₂₀H₂₀N₂O₃S

Base Information

• Chemical Name: C₂₀H₂₀N₂O₃S
• CAS No.: 1334599-02-8
• Molecular Formula: C₂₀H₂₀N₂O₃S
• Molecular Weight: 368.456
• Mol file: 1334599-02-8.mol

Synonyms:

Chemical Property of C₂₀H₂₀N₂O₃S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₀N₂O₃S

There total 5 articles about C₂₀H₂₀N₂O₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclopentanone (120-92-3) → C20H20N2O3S (1334599-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfur / ethanol / 20 °C

1.2: 40 °C

2.1: dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sulfur; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2011.06.128

Reference yield:

methyl 2-methyl-3-furancarboxylate (6141-58-8) → C20H20N2O3S (1334599-02-8)

Guidance literature:

Multi-step reaction with 4 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 16 h / 85 °C

3: water; lithium hydroxide / methanol / Reflux

4: dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With dmap; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; 2: Suzuki cross coupling reaction;

DOI:10.1016/j.bmcl.2011.06.128

Reference yield:

C15H16O4 (1334598-59-2) → C20H20N2O3S (1334599-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1: water; lithium hydroxide / methanol / Reflux

2: dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With dmap; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2011.06.128

upstream raw materials:

C₁₅H₁₆O₄

methyl 2-methyl-3-furancarboxylate

cyclopentanone

methyl 5‐bromo‐2‐methylfuran‐3‐carboxylate