di-t-butyl 5-benzyloxycarbonyl-3,12-diethyl-2,8,8,13-tetramethyl-7,8,9,10,16,17-hexahydrotripyrrin-1,14-dicarboxylate

Base Information

• Chemical Name: di-t-butyl 5-benzyloxycarbonyl-3,12-diethyl-2,8,8,13-tetramethyl-7,8,9,10,16,17-hexahydrotripyrrin-1,14-dicarboxylate
• CAS No.: 95305-18-3
• Molecular Formula: C₄₀H₅₅N₃O₆
• Molecular Weight: 673.893
• Mol file: 95305-18-3.mol

Synonyms:

Chemical Property of di-t-butyl 5-benzyloxycarbonyl-3,12-diethyl-2,8,8,13-tetramethyl-7,8,9,10,16,17-hexahydrotripyrrin-1,14-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-t-butyl 5-benzyloxycarbonyl-3,12-diethyl-2,8,8,13-tetramethyl-7,8,9,10,16,17-hexahydrotripyrrin-1,14-dicarboxylate

There total 6 articles about di-t-butyl 5-benzyloxycarbonyl-3,12-diethyl-2,8,8,13-tetramethyl-7,8,9,10,16,17-hexahydrotripyrrin-1,14-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2--5-(3-ethyl-4-methyl-5-t-butoxycarbonylpyrrol-2-ylmethyl)-3,4-dihydro-4,4-dimethylpyrrole (95305-17-2,95305-27-4) → di-t-butyl 5-benzyloxycarbonyl-3,12-diethyl-2,8,8,13-tetramethyl-7,8,9,10,16,17-hexahydrotripyrrin-1,14-dicarboxylate (95305-18-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; phosphorous acid trimethyl ester; In benzene; at 60 ℃; for 44h; Yield given;

DOI:10.1039/P19840002733

Reference yield:

t-butyl 4-ethyl-3-methyl-5-(2-nitroethyl)pyrrole-2-carboxylate (79264-55-4) → di-t-butyl 5-benzyloxycarbonyl-3,12-diethyl-2,8,8,13-tetramethyl-7,8,9,10,16,17-hexahydrotripyrrin-1,14-dicarboxylate (95305-18-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 65 percent / tetrabutylammonium fluoride, 3A molecular sieve / dimethylformamide / 4 h / 50 °C

2: 69 percent / zinc dust / acetic acid / 1.5 h / Ambient temperature

3: titanium(II) chloride / 0.33 h

4: 54 percent / phosphorus pentasulphide, pyridine / acetonitrile / 1.) 15 min, 2.) 20 deg C, 62 h

5: 97 percent / potassium t-butoxide / 2-methyl-propan-2-ol; CCl₄ / 1.5 h

6: N,N-di-isopropylethylamine, trimethyl phosphite / benzene / 44 h / 60 °C

With pyridine; diphosphorus pentasulfide; 3 A molecular sieve; potassium tert-butylate; tetrabutyl ammonium fluoride; titanium chloride; N-ethyl-N,N-diisopropylamine; zinc; phosphorous acid trimethyl ester; In tetrachloromethane; acetic acid; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; benzene;

DOI:10.1039/P19840002733

Reference yield:

5-(3-ethyl-4-methyl-5-t-butoxycarbonylpyrrol-2-ylmethyl)-4,4-dimethylpyrrolidin-2-one (79264-57-6) → di-t-butyl 5-benzyloxycarbonyl-3,12-diethyl-2,8,8,13-tetramethyl-7,8,9,10,16,17-hexahydrotripyrrin-1,14-dicarboxylate (95305-18-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 54 percent / phosphorus pentasulphide, pyridine / acetonitrile / 1.) 15 min, 2.) 20 deg C, 62 h

2: 97 percent / potassium t-butoxide / 2-methyl-propan-2-ol; CCl₄ / 1.5 h

3: N,N-di-isopropylethylamine, trimethyl phosphite / benzene / 44 h / 60 °C

With pyridine; diphosphorus pentasulfide; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; phosphorous acid trimethyl ester; In tetrachloromethane; acetonitrile; tert-butyl alcohol; benzene;

DOI:10.1039/P19840002733

upstream raw materials:

2--5-(3-ethyl-4-methyl-5-t-butoxycarbonylpyrrol-2-ylmethyl)-3,4-dihydro-4,4-dimethylpyrrole

t-butyl 4-ethyl-3-methyl-5-(2-nitroethyl)pyrrole-2-carboxylate

5-(3-ethyl-4-methyl-5-t-butoxycarbonylpyrrol-2-ylmethyl)-4,4-dimethylpyrrolidin-2-one

5-(3-ethyl-4-methyl-5-t-butoxycarbonylpyrrol-2-ylmethyl)-4,4-dimethylpyrrolidin-2-thione