methyl (3-((R)-1-((R)-2-((1-aminoisoquinolin-6-yl)amino)-2-(3,4-dimethoxyphenyl)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenyl)carbamate trifluoroacetic acid salt

Base Information

Chemical Name:methyl (3-((R)-1-((R)-2-((1-aminoisoquinolin-6-yl)amino)-2-(3,4-dimethoxyphenyl)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenyl)carbamate trifluoroacetic acid salt
CAS No.:1520082-63-6
Molecular Formula:C₂HF₃O₂*C₃₄H₃₉N₅O₇S
Molecular Weight:775.803
Hs Code.:

methyl (3-((R)-1-((R)-2-((1-aminoisoquinolin-6-yl)amino)-2-(3,4-dimethoxyphenyl)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenyl)carbamate trifluoroacetic acid salt

Synonyms:

Suppliers and Price of methyl (3-((R)-1-((R)-2-((1-aminoisoquinolin-6-yl)amino)-2-(3,4-dimethoxyphenyl)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenyl)carbamate trifluoroacetic acid salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (3-((R)-1-((R)-2-((1-aminoisoquinolin-6-yl)amino)-2-(3,4-dimethoxyphenyl)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenyl)carbamate trifluoroacetic acid salt

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (3-((R)-1-((R)-2-((1-aminoisoquinolin-6-yl)amino)-2-(3,4-dimethoxyphenyl)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenyl)carbamate trifluoroacetic acid salt

There total 9 articles about methyl (3-((R)-1-((R)-2-((1-aminoisoquinolin-6-yl)amino)-2-(3,4-dimethoxyphenyl)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenyl)carbamate trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1520082-85-2
C₄₄H₅₅N₅O₁₁S

: 76-05-1
trifluoroacetic acid

: 1520082-63-6
methyl (3-((R)-1-((R)-2-((1-aminoisoquinolin-6-yl)amino)-2-(3,4-dimethoxyphenyl)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenyl)carbamate trifluoroacetic acid salt

Guidance literature:: C₄₄H₅₅N₅O₁₁S; With hydrogenchloride; In 1,4-dioxane; water; ethyl acetate; at 20 ℃; for 4h; Inert atmosphere;

trifluoroacetic acid; In water; at 20 ℃;
DOI:10.1021/ml400453z

Reference yield:

: 122775-35-3
3,4-Dimethoxyphenylboronic acid

: 1520082-63-6
methyl (3-((R)-1-((R)-2-((1-aminoisoquinolin-6-yl)amino)-2-(3,4-dimethoxyphenyl)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenyl)carbamate trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide; acetonitrile / 0.25 h / 105 °C / Microwave irradiation; Inert atmosphere

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / 20 °C / Inert atmosphere

3.1: hydrogenchloride / ethyl acetate; water; 1,4-dioxane / 4 h / 20 °C / Inert atmosphere

3.2: 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ml400453z

Reference yield:

: 745020-22-8
imidodicarbonic acid 2-(6-amino-1-isoquinolinyl)-1,3-bis(1,1-dimethylethyl)ester

: 1520082-63-6
methyl (3-((R)-1-((R)-2-((1-aminoisoquinolin-6-yl)amino)-2-(3,4-dimethoxyphenyl)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenyl)carbamate trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide; acetonitrile / 0.25 h / 105 °C / Microwave irradiation; Inert atmosphere

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / 20 °C / Inert atmosphere

3.1: hydrogenchloride / ethyl acetate; water; 1,4-dioxane / 4 h / 20 °C / Inert atmosphere

3.2: 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ml400453z