tert-Butyl-((2S,4S)-2,4-dimethyl-8-{2-[(R)-4-(toluene-4-sulfonylmethyl)-hexyl]-[1,3]dioxolan-2-yl}-octyloxy)-dimethyl-silane

Base Information

Chemical Name:tert-Butyl-((2S,4S)-2,4-dimethyl-8-{2-[(R)-4-(toluene-4-sulfonylmethyl)-hexyl]-[1,3]dioxolan-2-yl}-octyloxy)-dimethyl-silane
CAS No.:157733-72-7
Molecular Formula:C₃₃H₆₀O₅SSi
Molecular Weight:596.988
Hs Code.:

Synonyms:

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Chemical Property of tert-Butyl-((2S,4S)-2,4-dimethyl-8-{2-[(R)-4-(toluene-4-sulfonylmethyl)-hexyl]-[1,3]dioxolan-2-yl}-octyloxy)-dimethyl-silane

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Technology Process of tert-Butyl-((2S,4S)-2,4-dimethyl-8-{2-[(R)-4-(toluene-4-sulfonylmethyl)-hexyl]-[1,3]dioxolan-2-yl}-octyloxy)-dimethyl-silane

There total 12 articles about tert-Butyl-((2S,4S)-2,4-dimethyl-8-{2-[(R)-4-(toluene-4-sulfonylmethyl)-hexyl]-[1,3]dioxolan-2-yl}-octyloxy)-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 157733-72-7
tert-Butyl-((2S,4S)-2,4-dimethyl-8-{2-[(R)-4-(toluene-4-sulfonylmethyl)-hexyl]-[1,3]dioxolan-2-yl}-octyloxy)-dimethyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1: lutidine / CH₂Cl₂ / -20 °C

2: H₂ / 10percent Pd/C / ethanol / Ambient temperature

3: 95 percent / (COCl)2, Et₃N / CH₂Cl₂; dimethylsulfoxide / -60 deg C to r.t.

5: H₂ / Pd/C / ethanol / Ambient temperature

6: PPh₃, imidazole, I₂ / CH₂Cl₂ / Ambient temperature

7: dimethylformamide / Ambient temperature

With 1H-imidazole; oxalyl dichloride; lutidine; hydrogen; iodine; triethylamine; triphenylphosphine; palladium on activated charcoal; In ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19910740846

Reference yield:

: (2R,4S)-5-(tert-Butyl-dimethyl-silanyloxy)-2,4-dimethyl-pentanoic acid

: 157733-72-7
tert-Butyl-((2S,4S)-2,4-dimethyl-8-{2-[(R)-4-(toluene-4-sulfonylmethyl)-hexyl]-[1,3]dioxolan-2-yl}-octyloxy)-dimethyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / (COCl)2, Et₃N / CH₂Cl₂; dimethylsulfoxide / -60 deg C to r.t.

3: H₂ / Pd/C / ethanol / Ambient temperature

4: PPh₃, imidazole, I₂ / CH₂Cl₂ / Ambient temperature

5: dimethylformamide / Ambient temperature

With 1H-imidazole; oxalyl dichloride; hydrogen; iodine; triethylamine; triphenylphosphine; palladium on activated charcoal; In ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19910740846

Reference yield:

: 157733-59-0
[2R,4S]-5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-pentanoic acid methyl ester

: 157733-72-7
tert-Butyl-((2S,4S)-2,4-dimethyl-8-{2-[(R)-4-(toluene-4-sulfonylmethyl)-hexyl]-[1,3]dioxolan-2-yl}-octyloxy)-dimethyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1: LiAlH₄ / diethyl ether / Ambient temperature

2: 95 percent / (COCl)2, Et₃N / CH₂Cl₂; dimethylsulfoxide / -60 deg C to r.t.

4: H₂ / Pd/C / ethanol / Ambient temperature

5: PPh₃, imidazole, I₂ / CH₂Cl₂ / Ambient temperature

6: dimethylformamide / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; oxalyl dichloride; hydrogen; iodine; triethylamine; triphenylphosphine; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19910740846