2-Amino-7-benzyl-5-{[(E)-(3aR,4R,6aS)-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-ylimino]-methyl}-3-isopropoxymethyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

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Chemical Name:2-Amino-7-benzyl-5-{[(E)-(3aR,4R,6aS)-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-ylimino]-methyl}-3-isopropoxymethyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one
CAS No.:85460-58-8
Molecular Formula:C₂₆H₃₁N₅O₄
Molecular Weight:477.563
Hs Code.:

2-Amino-7-benzyl-5-{[(E)-(3aR,4R,6aS)-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-ylimino]-methyl}-3-isopropoxymethyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

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Chemical Property of 2-Amino-7-benzyl-5-{[(E)-(3aR,4R,6aS)-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-ylimino]-methyl}-3-isopropoxymethyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

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Technology Process of 2-Amino-7-benzyl-5-{[(E)-(3aR,4R,6aS)-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-ylimino]-methyl}-3-isopropoxymethyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

There total 5 articles about 2-Amino-7-benzyl-5-{[(E)-(3aR,4R,6aS)-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-ylimino]-methyl}-3-isopropoxymethyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69565-95-3
2-Amino-7-benzyl-6-bromo-5-hydroxymethyl-3-isopropoxymethyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

: 85460-58-8
2-Amino-7-benzyl-5-{[(E)-(3aR,4R,6aS)-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-ylimino]-methyl}-3-isopropoxymethyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.4 g / potassium acetate, H₂ / palladium / methanol

2: 685 mg / MnO₂ / benzene / 22 h / Ambient temperature

3: benzene / 17 h / Ambient temperature

With manganese(IV) oxide; hydrogen; potassium acetate; palladium; In methanol; benzene;
DOI:10.1246/cl.1983.419

Reference yield:

: 69565-89-5
N-(7-benzyl-6-bromo-5-bromomethyl-3-isopropoxymethyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)-diacetamide

: 85460-58-8
2-Amino-7-benzyl-5-{[(E)-(3aR,4R,6aS)-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-ylimino]-methyl}-3-isopropoxymethyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) silver carbonate; 2.) conc. ammonia / 1.) dioxane-water, r.t., 16 h; 2.) methanol, r.t., 16 h

2: 1.4 g / potassium acetate, H₂ / palladium / methanol

3: 685 mg / MnO₂ / benzene / 22 h / Ambient temperature

4: benzene / 17 h / Ambient temperature

With manganese(IV) oxide; ammonium hydroxide; hydrogen; potassium acetate; silver carbonate; palladium; In methanol; benzene;
DOI:10.1246/cl.1983.419

Reference yield:

: 72278-31-0
N-(7-benzyl-6-bromo-3-isopropoxymethyl-5-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)-diacetamide

: 85460-58-8
2-Amino-7-benzyl-5-{[(E)-(3aR,4R,6aS)-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-ylimino]-methyl}-3-isopropoxymethyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: N-bromosuccinimide, potassium carbonate, benzoyl peroxide / CCl₄ / 5 h / Heating

2: 1.) silver carbonate; 2.) conc. ammonia / 1.) dioxane-water, r.t., 16 h; 2.) methanol, r.t., 16 h

3: 1.4 g / potassium acetate, H₂ / palladium / methanol

4: 685 mg / MnO₂ / benzene / 22 h / Ambient temperature

5: benzene / 17 h / Ambient temperature

With manganese(IV) oxide; ammonium hydroxide; N-Bromosuccinimide; Perbenzoic acid; hydrogen; potassium acetate; potassium carbonate; silver carbonate; palladium; In methanol; tetrachloromethane; benzene;
DOI:10.1246/cl.1983.419