Technology Process of (2R,3R,4S,6R)-6-Methoxy-2,4-dimethyl-3-phenoxy-tetrahydro-pyran-4-ol
There total 17 articles about (2R,3R,4S,6R)-6-Methoxy-2,4-dimethyl-3-phenoxy-tetrahydro-pyran-4-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
methanol;
at 25 ℃;
for 24h;
DOI:10.1021/jo00273a030
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1.) LDA / 1.) THF, -78 deg C, 20 min, 2.) 1 min
2: tetrahydrofuran / 0.5 h / -78 °C
3: aq. H2SO4 / diethyl ether / 16 h
5: 95 percent / diisobutylaluminum hydride / toluene; diethyl ether / 0.5 h / -78 °C
6: 1.) KH, 2.) LDA / 1.) THF, 0 deg C, 2.) 25 deg C, 24 h
7: 1.) Hg(OAc)2, 2.) NaBH4 / 1.) THF, 25 deg C, 100 min, 2.) methanol, 0 deg C, 20 min
8: TsOH / methanol / 24 h / 25 °C
With
sodium tetrahydroborate; sulfuric acid; mercury(II) diacetate; potassium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; diethyl ether; toluene;
DOI:10.1021/jo00273a030
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) LDA / 1.) THF, -78 deg C, 20 min, 2.) 1 min
2: tetrahydrofuran / 0.5 h / -78 °C
3: aq. H2SO4 / diethyl ether / 16 h
5: diisobutylaluminum hydride / toluene; diethyl ether / 0.5 h / -78 °C
6: 1.) KH, 2.) LDA / 1.) THF, 0 deg C, 2.) 25 deg C, 24 h
7: 1.) Hg(OAc)2, 2.) NaBH4 / 1.) THF, 25 deg C, 100 min, 2.) methanol, 0 deg C, 20 min
With
sodium tetrahydroborate; sulfuric acid; mercury(II) diacetate; potassium hydride; diisobutylaluminium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; toluene;
DOI:10.1021/jo00273a030
