8-hydroxymethyl-2'-O-tosyladenosine

Base Information

Chemical Name:8-hydroxymethyl-2'-O-tosyladenosine
CAS No.:101904-44-3
Molecular Formula:C₁₈H₂₁N₅O₇S
Molecular Weight:451.46
Hs Code.:

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Chemical Property of 8-hydroxymethyl-2'-O-tosyladenosine

Chemical Property:

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Technology Process of 8-hydroxymethyl-2'-O-tosyladenosine

There total 4 articles about 8-hydroxymethyl-2'-O-tosyladenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 70255-53-7
5'-O-acetyl-8-cyano-2',3'-O-isopropylideneadenosine

: 101904-44-3
8-hydroxymethyl-2'-O-tosyladenosine

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / LiAlH₄ / tetrahydrofuran / 0.5 h

2: 53 percent / iso-AmONO, CF₃COOH / dimethylformamide / 0.5 h / Ambient temperature

3: 84 percent / 50 percent HCO₂H / Ambient temperature

4: 1.) di-n-butyltin oxide; 2.) Et₃N / 1.) MeOH, reflux, 2 h; 2.) MeOH, 30 min

With lithium aluminium tetrahydride; formic acid; di(n-butyl)tin oxide; triethylamine; trifluoroacetic acid; isopentyl nitrite; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.33.3263

Reference yield:

: 101904-40-9
8-aminomethyl-2',3'-O-isopropylideneadenosine

: 101904-44-3
8-hydroxymethyl-2'-O-tosyladenosine

Guidance literature:: Multi-step reaction with 3 steps

1: 53 percent / iso-AmONO, CF₃COOH / dimethylformamide / 0.5 h / Ambient temperature

2: 84 percent / 50 percent HCO₂H / Ambient temperature

3: 1.) di-n-butyltin oxide; 2.) Et₃N / 1.) MeOH, reflux, 2 h; 2.) MeOH, 30 min

With formic acid; di(n-butyl)tin oxide; triethylamine; trifluoroacetic acid; isopentyl nitrite; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.33.3263

Reference yield:

: 101904-41-0
8-(hydroxymethyl)-2',3'-O-isopropylideneadenosine

: 101904-44-3
8-hydroxymethyl-2'-O-tosyladenosine

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / 50 percent HCO₂H / Ambient temperature

2: 1.) di-n-butyltin oxide; 2.) Et₃N / 1.) MeOH, reflux, 2 h; 2.) MeOH, 30 min

With formic acid; di(n-butyl)tin oxide; triethylamine;
DOI:10.1248/cpb.33.3263