2,6-diamino-8-bromo-9-(2'-O-tosyl-β-D-ribufuranosyl)-purine

Base Information

Chemical Name:2,6-diamino-8-bromo-9-(2'-O-tosyl-β-D-ribufuranosyl)-purine
CAS No.:81102-46-7
Molecular Formula:C₁₇H₁₉BrN₆O₆S
Molecular Weight:515.344
Hs Code.:

Synonyms:

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Chemical Property of 2,6-diamino-8-bromo-9-(2'-O-tosyl-β-D-ribufuranosyl)-purine

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Technology Process of 2,6-diamino-8-bromo-9-(2'-O-tosyl-β-D-ribufuranosyl)-purine

There total 3 articles about 2,6-diamino-8-bromo-9-(2'-O-tosyl-β-D-ribufuranosyl)-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79999-39-6,24638-99-1
2',3',5'-tri-O-acetyl-2-chloroadenosine

: 81102-46-7
2,6-diamino-8-bromo-9-(2'-O-tosyl-β-D-ribufuranosyl)-purine

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / ammonia gas / ethanol / 10 h / 100 °C

2: 92 percent / saturated bromine-water / 1 h / Ambient temperature

3: 1.) dibutyltin oxide, 2.) triethylamine / 1.) methanol, 5 h, reflux, 2.) methanol, 1 h, room temperature

With ammonia; bromine; di(n-butyl)tin oxide; triethylamine; In ethanol;
DOI:10.1248/cpb.29.3449

Reference yield:

: 2096-10-8
adenosine-2-amine

: 81102-46-7
2,6-diamino-8-bromo-9-(2'-O-tosyl-β-D-ribufuranosyl)-purine

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / saturated bromine-water / 1 h / Ambient temperature

2: 1.) dibutyltin oxide, 2.) triethylamine / 1.) methanol, 5 h, reflux, 2.) methanol, 1 h, room temperature

With bromine; di(n-butyl)tin oxide; triethylamine;
DOI:10.1248/cpb.29.3449

Reference yield:

: 81102-44-5
9-(β-D-ribofuranosyl)-2,6-diamino-8-bromopurine

: 98-59-9
p-toluenesulfonyl chloride

: 81102-46-7
2,6-diamino-8-bromo-9-(2'-O-tosyl-β-D-ribufuranosyl)-purine

Guidance literature:: With di(n-butyl)tin oxide; triethylamine; Yield given. Multistep reaction; 1.) methanol, 5 h, reflux, 2.) methanol, 1 h, room temperature;
DOI:10.1248/cpb.29.3449