1-[(8R,9S,10R,13S,14S,17S)-17-(tert-Butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-2-yl]-ethanone

Base Information

Chemical Name:1-[(8R,9S,10R,13S,14S,17S)-17-(tert-Butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-2-yl]-ethanone
CAS No.:144657-00-1
Molecular Formula:C₃₇H₅₀O₂Si
Molecular Weight:554.888
Hs Code.:

1-[(8R,9S,10R,13S,14S,17S)-17-(tert-Butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-2-yl]-ethanone

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Chemical Property of 1-[(8R,9S,10R,13S,14S,17S)-17-(tert-Butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-2-yl]-ethanone

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Technology Process of 1-[(8R,9S,10R,13S,14S,17S)-17-(tert-Butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-2-yl]-ethanone

There total 3 articles about 1-[(8R,9S,10R,13S,14S,17S)-17-(tert-Butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-2-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 132833-27-3,132833-28-4
tert-butyl<(3-methylene-5-vinyl-4-oxaandrostan-17β-yl)oxy>diphenylsilane

: 132833-37-5
17β-(tert-butyldiphenylsiloxy)-A-dihomoandrost-4b-en-3-one

: 144656-99-5,144657-08-9
tert-Butyl-diphenyl-((8S,9S,10R,13S,14S,17S)-3,10,13-trimethyl-5-vinyl-1,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-4-oxa-cyclopenta[a]phenanthren-17-yloxy)-silane

: 144657-00-1,144657-09-0
1-[(8R,9S,10R,13S,14S,17S)-17-(tert-Butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-2-yl]-ethanone

Guidance literature:: In toluene; at 190 ℃; for 48h; KOH-coated soft-glass tube (sealed);

Reference yield:

: 144656-97-3,144657-06-7
17β-(tert-butyldiphenylsiloxy)-4α,5-epoxy-A-homo-4-oxaandrostan-3-one

: 144657-00-1,144657-09-0
1-[(8R,9S,10R,13S,14S,17S)-17-(tert-Butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-2-yl]-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / 10-camphor-d-sulfonic acid / benzene / 24 h / Ambient temperature

2: 92 percent / pyridine / tetrahydrofuran; CH₂Cl₂; toluene / -40 deg C, 15 min, then 25 deg C, 90 min

3: 29 percent / toluene / 48 h / 190 °C / KOH-coated soft-glass tube (sealed)

With pyridine; camphor-10-sulfonic acid; In tetrahydrofuran; dichloromethane; toluene; benzene;

Reference yield:

: 132833-26-2,132833-36-4
17β-(tert-butyldiphenylsiloxy)-3-oxo-4-oxaandrostane-5-carboxaldehyde

: 144657-00-1,144657-09-0
1-[(8R,9S,10R,13S,14S,17S)-17-(tert-Butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-2-yl]-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / pyridine / tetrahydrofuran; CH₂Cl₂; toluene / -40 deg C, 15 min, then 25 deg C, 90 min

2: 29 percent / toluene / 48 h / 190 °C / KOH-coated soft-glass tube (sealed)

With pyridine; In tetrahydrofuran; dichloromethane; toluene;