Thiocarbonic acid S-[(2R,3S)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-1-(2-oxo-3-oxa-bicyclo[3.1.0]hex-1-yl)-azetidin-2-yl] ester O-phenyl ester

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Chemical Name:Thiocarbonic acid S-[(2R,3S)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-1-(2-oxo-3-oxa-bicyclo[3.1.0]hex-1-yl)-azetidin-2-yl] ester O-phenyl ester
CAS No.:144533-87-9
Molecular Formula:C₂₃H₃₁NO₆SSi
Molecular Weight:477.654
Hs Code.:

Thiocarbonic acid S-[(2R,3S)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-1-(2-oxo-3-oxa-bicyclo[3.1.0]hex-1-yl)-azetidin-2-yl] ester O-phenyl ester

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Chemical Property of Thiocarbonic acid S-[(2R,3S)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-1-(2-oxo-3-oxa-bicyclo[3.1.0]hex-1-yl)-azetidin-2-yl] ester O-phenyl ester

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Technology Process of Thiocarbonic acid S-[(2R,3S)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-1-(2-oxo-3-oxa-bicyclo[3.1.0]hex-1-yl)-azetidin-2-yl] ester O-phenyl ester

There total 5 articles about Thiocarbonic acid S-[(2R,3S)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-1-(2-oxo-3-oxa-bicyclo[3.1.0]hex-1-yl)-azetidin-2-yl] ester O-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144533-81-3
{(3S,4R)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-phenoxycarbonylsulfanyl-azetidin-1-yl}-oxo-acetic acid allyl ester

: 130516-16-4
{(3S,4R)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-phenoxycarbonylsulfanyl-azetidin-1-yl}-acetic acid allyl ester

: 144533-87-9
Thiocarbonic acid S-[(2R,3S)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-1-(2-oxo-3-oxa-bicyclo[3.1.0]hex-1-yl)-azetidin-2-yl] ester O-phenyl ester

Guidance literature:: With methyldiethoxyphosphine; dimethyl methylphosphonite; In chloroform; at 50 ℃; Yields of byproduct given;
DOI:10.1016/S0040-4039(00)79085-X

Reference yield:

: 76899-07-5,78963-47-0,78963-48-1,78963-60-7,80951-41-3,81275-02-7,85647-75-2,85954-95-6,92217-74-8,104527-11-9,76855-69-1
(3R,4R)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-acetoxyazetidin-2-one

: 144533-87-9
Thiocarbonic acid S-[(2R,3S)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-1-(2-oxo-3-oxa-bicyclo[3.1.0]hex-1-yl)-azetidin-2-yl] ester O-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

2: 1) AgNO₃

4: MeP(OR)2 (R=Me, Et) / CHCl₃ / 50 °C

With methyldiethoxyphosphine; dimethyl methylphosphonite; silver nitrate; In chloroform;
DOI:10.1016/S0040-4039(00)79085-X

Reference yield:

: 74503-07-4
allyl oxalyl chloride

: 144533-87-9
Thiocarbonic acid S-[(2R,3S)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-1-(2-oxo-3-oxa-bicyclo[3.1.0]hex-1-yl)-azetidin-2-yl] ester O-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

2: MeP(OR)2 (R=Me, Et) / CHCl₃ / 50 °C

With methyldiethoxyphosphine; dimethyl methylphosphonite; In chloroform;
DOI:10.1016/S0040-4039(00)79085-X