Technology Process of (7E,9E)-trisporic acid A
There total 10 articles about (7E,9E)-trisporic acid A which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 98 percent / triethylamine / tetrahydrofuran / 6 h / Heating
2: 95 percent / p-toluenesulfonic acid / benzene / 36 h / Heating
3: 100 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / 3 h / Heating
4: 89 percent / water / 0.08 h / 100 °C
5: 1.) n-butyllithium, 2.) hexamethylphosphoramide / 1.) THF, hexane, 15 min, 2.) THF, hexane, -78 deg C, 2 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; N-Bromosuccinimide; n-butyllithium; Perbenzoic acid; water; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; tetrachloromethane; benzene;
DOI:10.1021/jo00225a049
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) sodium hydride / 1.) THF, RT, 1.5 h, 2.) THF, 3 h
2: 81 percent / LiAlH4 / diethyl ether / 1.5 h
3: 95 percent / phosphorus tribromide / diethyl ether / 1.5 h
4: 76 percent / benzene
5: 1.) n-butyllithium, 2.) hexamethylphosphoramide / 1.) THF, hexane, 15 min, 2.) THF, hexane, -78 deg C, 2 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; n-butyllithium; phosphorus tribromide; sodium hydride;
In
diethyl ether; benzene;
DOI:10.1021/jo00225a049
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 98 percent / triethylamine / tetrahydrofuran / 6 h / Heating
2: 95 percent / p-toluenesulfonic acid / benzene / 36 h / Heating
3: 100 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / 3 h / Heating
4: 89 percent / water / 0.08 h / 100 °C
5: 1.) n-butyllithium, 2.) hexamethylphosphoramide / 1.) THF, hexane, 15 min, 2.) THF, hexane, -78 deg C, 2 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; N-Bromosuccinimide; n-butyllithium; Perbenzoic acid; water; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; tetrachloromethane; benzene;
DOI:10.1021/jo00225a049
