4-(3-(1-benzyl-2-chloro-1H-imidazol-4-yl)-1-hydroxy-1H-pyrazol-4-yl)piperidinium hydrogen bromide

Base Information

Chemical Name:4-(3-(1-benzyl-2-chloro-1H-imidazol-4-yl)-1-hydroxy-1H-pyrazol-4-yl)piperidinium hydrogen bromide
CAS No.:1449431-55-3
Molecular Formula:BrH*C₁₈H₂₀ClN₅O
Molecular Weight:438.755
Hs Code.:

Synonyms:

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Chemical Property of 4-(3-(1-benzyl-2-chloro-1H-imidazol-4-yl)-1-hydroxy-1H-pyrazol-4-yl)piperidinium hydrogen bromide

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Technology Process of 4-(3-(1-benzyl-2-chloro-1H-imidazol-4-yl)-1-hydroxy-1H-pyrazol-4-yl)piperidinium hydrogen bromide

There total 5 articles about 4-(3-(1-benzyl-2-chloro-1H-imidazol-4-yl)-1-hydroxy-1H-pyrazol-4-yl)piperidinium hydrogen bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1449431-48-4
methyl 4-(3-(1-benzyl-2-chloro-1H-imidazol-4-yl)-1-(benzyloxy)-1H-pyrazol-4-yl)piperidine-1-carboxylate

: 1449431-55-3
4-(3-(1-benzyl-2-chloro-1H-imidazol-4-yl)-1-hydroxy-1H-pyrazol-4-yl)piperidinium hydrogen bromide

Guidance literature:: With hydrogen bromide; In water; for 4h; Reflux;
DOI:10.1021/jm4006466

Reference yield:

: 1-benzyl-4-bromo-2-chloro-1H-imidazole

: 1449431-55-3
4-(3-(1-benzyl-2-chloro-1H-imidazol-4-yl)-1-hydroxy-1H-pyrazol-4-yl)piperidinium hydrogen bromide

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropylmagnesium chloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride; copper(l) iodide / N,N-dimethyl-formamide / 72 h / 110 °C / Inert atmosphere

3.1: hydrogen bromide / water / 4 h / Reflux

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; isopropylmagnesium chloride; cesium fluoride; In dichloromethane; water; N,N-dimethyl-formamide; 2.1: |Stille Cross Coupling;
DOI:10.1021/jm4006466

Reference yield:

: 106848-38-8
1-benzyl-4-bromo-1H-imidazole

: 1449431-55-3
4-(3-(1-benzyl-2-chloro-1H-imidazol-4-yl)-1-hydroxy-1H-pyrazol-4-yl)piperidinium hydrogen bromide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 19 h / -78 - 20 °C / Inert atmosphere

2.1: isopropylmagnesium chloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride; copper(l) iodide / N,N-dimethyl-formamide / 72 h / 110 °C / Inert atmosphere

4.1: hydrogen bromide / water / 4 h / Reflux

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; hydrogen bromide; isopropylmagnesium chloride; cesium fluoride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 3.1: |Stille Cross Coupling;
DOI:10.1021/jm4006466