2-{[(2,4-Dimethoxyphenyl)methyl]amino}-N-phenylbenzamide

Base Information

• Chemical Name: 2-{[(2,4-Dimethoxyphenyl)methyl]amino}-N-phenylbenzamide
• CAS No.: 139602-64-5
• Molecular Formula: C22H22N2O3
• Molecular Weight: 362.428
• DSSTox Substance ID: DTXSID30566902
• Wikidata: Q82452671
• Mol file: 139602-64-5.mol

Synonyms:139602-64-5;2-{[(2,4-Dimethoxyphenyl)methyl]amino}-N-phenylbenzamide;DTXSID30566902

Chemical Property of 2-{[(2,4-Dimethoxyphenyl)methyl]amino}-N-phenylbenzamide

Chemical Property:

• XLogP3: 4.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 362.16304257
• Heavy Atom Count: 27
• Complexity: 453

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)CNC2=CC=CC=C2C(=O)NC3=CC=CC=C3)OC

Technology Process of 2-{[(2,4-Dimethoxyphenyl)methyl]amino}-N-phenylbenzamide

There total 3 articles about 2-{[(2,4-Dimethoxyphenyl)methyl]amino}-N-phenylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-(2,4-dimethoxy-benzylideneamino)-N-phenyl-benzamide (143424-13-9) → 2-(2,4-Dimethoxy-benzylamino)-N-phenyl-benzamide (139602-64-5)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 2h; Ambient temperature;

DOI:10.1007/BF00772940

Reference yield:

2,4-Dimethoxybenzaldehyde (613-45-6) → 2-(2,4-Dimethoxy-benzylamino)-N-phenyl-benzamide (139602-64-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / ethanol / 0.5 h / Ambient temperature

2: 81 percent / sodium borohydride / ethanol / 2 h / Ambient temperature

With sodium tetrahydroborate; In ethanol;

DOI:10.1007/BF00772940

Reference yield:

2-aminobenzanilide (4424-17-3) → 2-(2,4-Dimethoxy-benzylamino)-N-phenyl-benzamide (139602-64-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / ethanol / 0.5 h / Ambient temperature

2: 81 percent / sodium borohydride / ethanol / 2 h / Ambient temperature

With sodium tetrahydroborate; In ethanol;

DOI:10.1007/BF00772940

upstream raw materials:

2-(2,4-dimethoxy-benzylideneamino)-N-phenyl-benzamide

2,4-Dimethoxybenzaldehyde

2-aminobenzanilide

Downstream raw materials:

2-[Acetyl-(2,4-dimethoxy-benzyl)-amino]-N-phenyl-benzamide

Refernces