1-({[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-trimethylsilanylmethyl-carbamoyl}-methyl)-4-oxo-cyclohexa-2,5-dienecarboxylic acid methyl ester

Base Information

• Chemical Name: 1-({[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-trimethylsilanylmethyl-carbamoyl}-methyl)-4-oxo-cyclohexa-2,5-dienecarboxylic acid methyl ester
• CAS No.: 152707-26-1
• Molecular Formula: C₃₀H₃₄N₂O₆SSi
• Molecular Weight: 578.761
• Mol file: 152707-26-1.mol

Synonyms:

Chemical Property of 1-({[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-trimethylsilanylmethyl-carbamoyl}-methyl)-4-oxo-cyclohexa-2,5-dienecarboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-({[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-trimethylsilanylmethyl-carbamoyl}-methyl)-4-oxo-cyclohexa-2,5-dienecarboxylic acid methyl ester

There total 3 articles about 1-({[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-trimethylsilanylmethyl-carbamoyl}-methyl)-4-oxo-cyclohexa-2,5-dienecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,O-bis(phenylsulfonyl)tryptophol (129265-17-4) → 1-({[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-trimethylsilanylmethyl-carbamoyl}-methyl)-4-oxo-cyclohexa-2,5-dienecarboxylic acid methyl ester (152707-26-1)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / acetonitrile

2: Et₃N / CH₂Cl₂

3: 1) n-BuLi / 1, 2) THF

4: PDC, BuO₂H, Et₃N

With dipyridinium dichromate; n-butyllithium; 1-butyl hydroperoxide; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4039(00)60637-8

Reference yield:

[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-trimethylsilanylmethyl-amine → 1-({[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-trimethylsilanylmethyl-carbamoyl}-methyl)-4-oxo-cyclohexa-2,5-dienecarboxylic acid methyl ester (152707-26-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂

2: 1) n-BuLi / 1, 2) THF

3: PDC, BuO₂H, Et₃N

With dipyridinium dichromate; n-butyllithium; 1-butyl hydroperoxide; triethylamine; In dichloromethane;

DOI:10.1016/S0040-4039(00)60637-8

Reference yield:

1-({[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-trimethylsilanylmethyl-carbamoyl}-methyl)-cyclohexa-2,5-dienecarboxylic acid methyl ester (153894-94-1) → 1-({[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-trimethylsilanylmethyl-carbamoyl}-methyl)-4-oxo-cyclohexa-2,5-dienecarboxylic acid methyl ester (152707-26-1)

Guidance literature:

With dipyridinium dichromate; 1-butyl hydroperoxide; triethylamine; Yield given;

DOI:10.1016/S0040-4039(00)60637-8

upstream raw materials:

1-({[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-trimethylsilanylmethyl-carbamoyl}-methyl)-cyclohexa-2,5-dienecarboxylic acid methyl ester

N,O-bis(phenylsulfonyl)tryptophol