<(2R,4aR,5aS,6S,11aS,12R,12aR)-4a,5a,6,11a,12,12a-hexahydro-6-hydroxy-5a-nitro-2-phenyl-2H,4H-<1,3>dioxino<4',5':5,6>pyrano<3,2-b><1>benzopyran-12-yl>acetat

Base Information

• Chemical Name: <(2R,4aR,5aS,6S,11aS,12R,12aR)-4a,5a,6,11a,12,12a-hexahydro-6-hydroxy-5a-nitro-2-phenyl-2H,4H-<1,3>dioxino<4',5':5,6>pyrano<3,2-b><1>benzopyran-12-yl>acetat
• CAS No.: 131570-02-0
• Molecular Formula: C₂₂H₂₁NO₉
• Molecular Weight: 443.41
• Mol file: 131570-02-0.mol

Synonyms:

Chemical Property of <(2R,4aR,5aS,6S,11aS,12R,12aR)-4a,5a,6,11a,12,12a-hexahydro-6-hydroxy-5a-nitro-2-phenyl-2H,4H-<1,3>dioxino<4',5':5,6>pyrano<3,2-b><1>benzopyran-12-yl>acetat

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <(2R,4aR,5aS,6S,11aS,12R,12aR)-4a,5a,6,11a,12,12a-hexahydro-6-hydroxy-5a-nitro-2-phenyl-2H,4H-<1,3>dioxino<4',5':5,6>pyrano<3,2-b><1>benzopyran-12-yl>acetat

There total 2 articles about <(2R,4aR,5aS,6S,11aS,12R,12aR)-4a,5a,6,11a,12,12a-hexahydro-6-hydroxy-5a-nitro-2-phenyl-2H,4H-<1,3>dioxino<4',5':5,6>pyrano<3,2-b><1>benzopyran-12-yl>acetat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-O-Acetyl-4,6-O-benzyliden-1,2-didesoxy-1-nitro-D-arabino-hex-1-enopyranose (105874-30-4,105929-04-2) + salicylaldehyde (90-02-8) → <(2R,4aR,5aS,6R,11aS,12R,12aR)-4a,5a,6,11a,12,12a-hexahydro-6-hydroxy-5a-nitro-2-phenyl-2H,4H-<1,3>dioxino<4',5':5,6>pyrano<3,2-b><1>benzopyran-12-yl>acetat (131570-02-0,131615-91-3) + <(2R,4aR,5aS,6S,11aS,12R,12aR)-4a,5a,6,11a,12,12a-hexahydro-6-hydroxy-5a-nitro-2-phenyl-2H,4H-<1,3>dioxino<4',5':5,6>pyrano<3,2-b><1>benzopyran-12-yl>acetat (131570-02-0,131615-91-3)

Guidance literature:

With aluminum oxide; tetrabutyl ammonium fluoride; Yield given. Multistep reaction. Yields of byproduct given; 1) MeCN, sonication, r.t., 2.5 h, 2) r.t.;

DOI:10.1002/hlca.19900730715

Reference yield:

3-O-Acetyl-4,6-O-benzyliden-1,2-didesoxy-1-nitro-D-arabino-hex-1-enopyranose (105874-30-4,105929-04-2) + salicylaldehyde (90-02-8) → <(2R,4aR,5aS,6R,11aS,12R,12aR)-4a,5a,6,11a,12,12a-hexahydro-6-hydroxy-5a-nitro-2-phenyl-2H,4H-<1,3>dioxino<4',5':5,6>pyrano<3,2-b><1>benzopyran-12-yl>acetat (131570-02-0,131615-91-3) + <(2R,4aR,5aS,6S,11aS,12R,12aR)-4a,5a,6,11a,12,12a-hexahydro-6-hydroxy-5a-nitro-2-phenyl-2H,4H-<1,3>dioxino<4',5':5,6>pyrano<3,2-b><1>benzopyran-12-yl>acetat (131570-02-0,131615-91-3)

Guidance literature:

With aluminum oxide; tetrabutyl ammonium fluoride; Yield given. Multistep reaction. Yields of byproduct given; 1) MeCN, sonication, r.t., 2.5 h, 2) r.t.;

DOI:10.1002/hlca.19900730715

Reference yield: 45.0%

<(2R,4aR,5aS,6R,11aS,12R,12aR)-4a,5a,6,11a,12,12a-hexahydro-6-hydroxy-5a-nitro-2-phenyl-2H,4H-<1,3>dioxino<4',5':5,6>pyrano<3,2-b><1>benzopyran-12-yl>acetat (131570-02-0,131615-91-3) → <(2R,4aR,5aR,11aS,12R,12aR)-4a,5a,6,11a,12,12a-hexahydro-5a-nitro-6-oxo-2-phenyl-2H,4H-<1,3>dioxino<4',5':5,6>pyrano<3,2-b><1>benzopyran-12-yl>acetat (131570-04-2)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; Ambient temperature;

DOI:10.1002/hlca.19900730715

upstream raw materials:

3-O-Acetyl-4,6-O-benzyliden-1,2-didesoxy-1-nitro-D-arabino-hex-1-enopyranose

salicylaldehyde

Downstream raw materials:

Acetic acid (2R,4aR,5aS,6R,11aR,12R,12aR)-6-hydroxy-2-phenyl-4a,5a,6,11a,12,12a-hexahydro-4H-1,3,5,11-tetraoxa-naphthacen-12-yl ester

Acetic acid (2R,4aR,5aS,6S,11aR,12R,12aR)-6-hydroxy-2-phenyl-4a,5a,6,11a,12,12a-hexahydro-4H-1,3,5,11-tetraoxa-naphthacen-12-yl ester

Acetic acid (2R,4aR,5aS,6R,11aS,12R,12aR)-6-hydroxy-2-phenyl-4a,5a,6,11a,12,12a-hexahydro-4H-1,3,5,11-tetraoxa-naphthacen-12-yl ester

<(2R,4aR,5aR,6R,11aR,12R,12aR)-4a,5a,6,11a,12,12a-hexahydro-6-oxo-2-phenyl-2H,4H-<1,3>dioxino<4',5':5,6>pyrano<3,2-b><1>benzopyran-12-yl>-acetate