Benzoic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-[(2R,3R,4R,5S,6R)-5-acetoxy-6-acetoxymethyl-3-acetylamino-4-((S)-1-methoxycarbonyl-ethoxy)-tetrahydro-pyran-2-yloxymethyl]-5-acetylamino-6-benzyloxy-tetrahydro-pyran-4-yl ester

Base Information

• Chemical Name: Benzoic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-[(2R,3R,4R,5S,6R)-5-acetoxy-6-acetoxymethyl-3-acetylamino-4-((S)-1-methoxycarbonyl-ethoxy)-tetrahydro-pyran-2-yloxymethyl]-5-acetylamino-6-benzyloxy-tetrahydro-pyran-4-yl ester
• CAS No.: 81629-41-6
• Molecular Formula: C₄₀H₅₀N₂O₁₇
• Molecular Weight: 830.84

Synonyms:

Chemical Property of Benzoic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-[(2R,3R,4R,5S,6R)-5-acetoxy-6-acetoxymethyl-3-acetylamino-4-((S)-1-methoxycarbonyl-ethoxy)-tetrahydro-pyran-2-yloxymethyl]-5-acetylamino-6-benzyloxy-tetrahydro-pyran-4-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Useful:

Technology Process of Benzoic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-[(2R,3R,4R,5S,6R)-5-acetoxy-6-acetoxymethyl-3-acetylamino-4-((S)-1-methoxycarbonyl-ethoxy)-tetrahydro-pyran-2-yloxymethyl]-5-acetylamino-6-benzyloxy-tetrahydro-pyran-4-yl ester

There total 10 articles about Benzoic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-[(2R,3R,4R,5S,6R)-5-acetoxy-6-acetoxymethyl-3-acetylamino-4-((S)-1-methoxycarbonyl-ethoxy)-tetrahydro-pyran-2-yloxymethyl]-5-acetylamino-6-benzyloxy-tetrahydro-pyran-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

acetic anhydride (108-24-7) + benzyl 2-acetamido-6-O-<2-acetamido-4,6-di-O-acetyl-2-deoxy-3-O--β-D-glucopyranosyl>-3-O-benzoyl-2-deoxy-α-D-glucopyranoside (81629-40-5) → Benzoic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-[(2R,3R,4R,5S,6R)-5-acetoxy-6-acetoxymethyl-3-acetylamino-4-((S)-1-methoxycarbonyl-ethoxy)-tetrahydro-pyran-2-yloxymethyl]-5-acetylamino-6-benzyloxy-tetrahydro-pyran-4-yl ester (81629-41-6)

Guidance literature:

With pyridine; for 4h; Ambient temperature;

DOI:10.1016/S0008-6215(00)81038-1

Reference yield:

benzyl 2-acetamido-4,6-di-O-acetyl-2-deoxy-3-O--α-D-glucopyranoside (79957-36-1,81629-37-0) → Benzoic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-[(2R,3R,4R,5S,6R)-5-acetoxy-6-acetoxymethyl-3-acetylamino-4-((S)-1-methoxycarbonyl-ethoxy)-tetrahydro-pyran-2-yloxymethyl]-5-acetylamino-6-benzyloxy-tetrahydro-pyran-4-yl ester (81629-41-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 95 percent / hydrogen / 10percent Pd/C / methanol; H₂O; acetic acid / 6.5 h / 30 - 35 °C

2: acetyl chloride / 1,2-dichloro-ethane / 22 h / Ambient temperature

3: acetic acid / 1 h / Ambient temperature

4: 94 percent / ferric chloride / CH₂Cl₂ / 1.5 h / Ambient temperature

5: 86 percent / toluene-p-sulfonic acid monohydrate / CH₂Cl₂ / 30 h / 50 - 60 °C

6: 98 percent / pyridine / 4 h / Ambient temperature

With pyridine; hydrogen; iron(III) chloride; toluene-4-sulfonic acid; acetyl chloride; palladium on activated charcoal; In methanol; dichloromethane; water; acetic acid; 1,2-dichloro-ethane;

DOI:10.1016/S0008-6215(00)81038-1

Reference yield:

N-((4aR,6S,7R,8R,8aS)-6-(benzyloxy)-8-hydroxy-2,2-dimethylhexahydropyrano[3,2-d][1,3]dioxin-7-yl)acetamide (66026-10-6) → Benzoic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-[(2R,3R,4R,5S,6R)-5-acetoxy-6-acetoxymethyl-3-acetylamino-4-((S)-1-methoxycarbonyl-ethoxy)-tetrahydro-pyran-2-yloxymethyl]-5-acetylamino-6-benzyloxy-tetrahydro-pyran-4-yl ester (81629-41-6)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine

2: 70percent aqueous acetic acid / 1 h / 40 - 45 °C

3: 86 percent / toluene-p-sulfonic acid monohydrate / CH₂Cl₂ / 30 h / 50 - 60 °C

4: 98 percent / pyridine / 4 h / Ambient temperature

With pyridine; toluene-4-sulfonic acid; acetic acid; In dichloromethane;

DOI:10.1016/S0008-6215(00)81038-1

upstream raw materials:

acetic anhydride

benzyl 2-acetamido-6-O-<2-acetamido-4,6-di-O-acetyl-2-deoxy-3-O--β-D-glucopyranosyl>-3-O-benzoyl-2-deoxy-α-D-glucopyranoside

N-((4aR,6S,7R,8R,8aS)-6-(benzyloxy)-8-hydroxy-2,2-dimethylhexahydropyrano[3,2-d][1,3]dioxin-7-yl)acetamide

benzoyl chloride

Downstream raw materials:

Benzoic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-[(2R,3R,4R,5S,6R)-5-acetoxy-6-acetoxymethyl-3-acetylamino-4-((S)-1-carboxy-ethoxy)-tetrahydro-pyran-2-yloxymethyl]-5-acetylamino-6-benzyloxy-tetrahydro-pyran-4-yl ester

benzyl 2-acetamido-6-O-<2-acetamido-2-deoxy-3-O-(D-2-propanoyl-L-alanyl-D-isoglutamine)-β-D-glucopyranosyl>-2-deoxy-α-D-glucopyranoside

benzyl 2-acetamido-6-O-<2-acetamido-4,6-di-O-acetyl-2-deoxy-3-O-(D-2-propanoyl-L-alanyl-D-isoglutamine benzyl ester)-β-D-glucopyranosyl>-4-O-acetyl-3-O-benzoyl-2-deoxy-α-D-glucopyranoside

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