(1R,3S,5S)-8-tert-butyl 3-methyl 3-(2-aminoethyl)-8-azabicyclo[3.2.1]octane-3,8-dicarboxylate

Base Information

Chemical Name:(1R,3S,5S)-8-tert-butyl 3-methyl 3-(2-aminoethyl)-8-azabicyclo[3.2.1]octane-3,8-dicarboxylate
CAS No.:1548292-06-3
Molecular Formula:C₁₆H₂₈N₂O₄
Molecular Weight:312.409
Hs Code.:

Synonyms:

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Chemical Property of (1R,3S,5S)-8-tert-butyl 3-methyl 3-(2-aminoethyl)-8-azabicyclo[3.2.1]octane-3,8-dicarboxylate

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Technology Process of (1R,3S,5S)-8-tert-butyl 3-methyl 3-(2-aminoethyl)-8-azabicyclo[3.2.1]octane-3,8-dicarboxylate

There total 8 articles about (1R,3S,5S)-8-tert-butyl 3-methyl 3-(2-aminoethyl)-8-azabicyclo[3.2.1]octane-3,8-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1548292-02-9
(1R,3S,5S)-8-tert-butyl 3-methyl 3-(cyanomethyl)-8-azabicyclo[3.2.1]octane-3,8-dicarboxylate

: 1548292-06-3
(1R,3S,5S)-8-tert-butyl 3-methyl 3-(2-aminoethyl)-8-azabicyclo[3.2.1]octane-3,8-dicarboxylate

Guidance literature:: With platinum(IV) oxide; hydrogen; acetic acid; In ethanol; at 20 ℃; for 48h; under 2327.23 Torr;

Reference yield:

: (1R,5S,Z)-tert-butyl 3-(1-cyano-2-methoxy-2-oxoethylidene)-8-azabicyclo[3.2.1]octane-8-carboxylate

: 1548292-06-3
(1R,3S,5S)-8-tert-butyl 3-methyl 3-(2-aminoethyl)-8-azabicyclo[3.2.1]octane-3,8-dicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: copper(l) iodide / tetrahydrofuran / 1 h / -10 °C

2: sodium chloride; water / dimethyl sulfoxide / 2 h / 160 °C

3: osmium(VIII) oxide; sodium periodate; water / 1,4-dioxane / 17 h / 20 °C

4: sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; sodium chlorite / water; tert-butyl alcohol / 1 h / 0 °C

5: methanol; dichloromethane / 0.5 h / 20 °C

6: acetic acid; platinum(IV) oxide; hydrogen / ethanol / 48 h / 20 °C / 2327.23 Torr

With platinum(IV) oxide; sodium chlorite; sodium periodate; copper(l) iodide; osmium(VIII) oxide; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; water; hydrogen; acetic acid; sodium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;

Reference yield:

: 185099-67-6
N-Boc-nortropinone

: 1548292-06-3
(1R,3S,5S)-8-tert-butyl 3-methyl 3-(2-aminoethyl)-8-azabicyclo[3.2.1]octane-3,8-dicarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: ammonium acetate; acetic acid / toluene / 150 °C / Dean-Stark

2: copper(l) iodide / tetrahydrofuran / 1 h / -10 °C

3: sodium chloride; water / dimethyl sulfoxide / 2 h / 160 °C

4: osmium(VIII) oxide; sodium periodate; water / 1,4-dioxane / 17 h / 20 °C

5: sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; sodium chlorite / water; tert-butyl alcohol / 1 h / 0 °C

6: methanol; dichloromethane / 0.5 h / 20 °C

7: acetic acid; platinum(IV) oxide; hydrogen / ethanol / 48 h / 20 °C / 2327.23 Torr

With platinum(IV) oxide; sodium chlorite; sodium periodate; copper(l) iodide; osmium(VIII) oxide; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; ammonium acetate; water; hydrogen; acetic acid; sodium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene; tert-butyl alcohol;