4-((4-((4-(2-(dimethylamino)ethoxy)phenyl)(cyclohexylidene)methyl)phenoxy)methyl)-7-dimethylaminocoumarin

Base Information

• Chemical Name: 4-((4-((4-(2-(dimethylamino)ethoxy)phenyl)(cyclohexylidene)methyl)phenoxy)methyl)-7-dimethylaminocoumarin
• CAS No.: 1246852-96-9
• Molecular Formula: C₃₅H₄₀N₂O₄
• Molecular Weight: 552.714
• Mol file: 1246852-96-9.mol

Synonyms:

Chemical Property of 4-((4-((4-(2-(dimethylamino)ethoxy)phenyl)(cyclohexylidene)methyl)phenoxy)methyl)-7-dimethylaminocoumarin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((4-((4-(2-(dimethylamino)ethoxy)phenyl)(cyclohexylidene)methyl)phenoxy)methyl)-7-dimethylaminocoumarin

There total 3 articles about 4-((4-((4-(2-(dimethylamino)ethoxy)phenyl)(cyclohexylidene)methyl)phenoxy)methyl)-7-dimethylaminocoumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

4-((4-(2-(dimethylamino)ethoxy)phenyl)(cyclohexylidene)methyl)-phenol (110024-82-3) + 7-(dimethylamino)-4-(hydroxymethyl)-2H-chromen-2-one (105567-75-7) → 4-((4-((4-(2-(dimethylamino)ethoxy)phenyl)(cyclohexylidene)methyl)phenoxy)methyl)-7-dimethylaminocoumarin (1246852-96-9)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; for 0.333333h; Sonication;

DOI:10.1002/cbic.201000008

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 4-((4-((4-(2-(dimethylamino)ethoxy)phenyl)(cyclohexylidene)methyl)phenoxy)methyl)-7-dimethylaminocoumarin (1246852-96-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: titanium tetrachloride; zinc / tetrahydrofuran / 0 °C / Reflux; Inert atmosphere

2.1: potassium carbonate / water; acetone / 0.5 h / 0 °C / Reflux

2.2: 0 °C / Reflux

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.33 h / Sonication

With di-isopropyl azodicarboxylate; titanium tetrachloride; potassium carbonate; triphenylphosphine; zinc; In tetrahydrofuran; water; acetone; 1.1: McMurry reaction;

DOI:10.1002/cbic.201000008

Reference yield:

4,4'-Dihydroxybenzophenone (611-99-4) → 4-((4-((4-(2-(dimethylamino)ethoxy)phenyl)(cyclohexylidene)methyl)phenoxy)methyl)-7-dimethylaminocoumarin (1246852-96-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: titanium tetrachloride; zinc / tetrahydrofuran / 0 °C / Reflux; Inert atmosphere

2.1: potassium carbonate / water; acetone / 0.5 h / 0 °C / Reflux

2.2: 0 °C / Reflux

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.33 h / Sonication

With di-isopropyl azodicarboxylate; titanium tetrachloride; potassium carbonate; triphenylphosphine; zinc; In tetrahydrofuran; water; acetone; 1.1: McMurry reaction;

DOI:10.1002/cbic.201000008

upstream raw materials:

4-((4-(2-(dimethylamino)ethoxy)phenyl)(cyclohexylidene)methyl)-phenol

7-(dimethylamino)-4-(hydroxymethyl)-2H-chromen-2-one

4,4'-Dihydroxybenzophenone

cyclohexanone