C₂₂H₂₅ClN₆O

Base Information

• Chemical Name: C₂₂H₂₅ClN₆O
• CAS No.: 1330075-39-2
• Molecular Formula: C₂₂H₂₅ClN₆O
• Molecular Weight: 424.933
• Mol file: 1330075-39-2.mol

Synonyms:

Chemical Property of C₂₂H₂₅ClN₆O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₅ClN₆O

There total 5 articles about C₂₂H₂₅ClN₆O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

C32H41ClN6O5 (1330075-62-1) → C22H25ClN6O (1330075-39-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1016/j.bmcl.2011.05.115

Reference yield:

methyl 2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (334018-52-9) → C22H25ClN6O (1330075-39-2)

Guidance literature:

Multi-step reaction with 4 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; tripotassium phosphate "n" hydrate / 1,4-dioxane; water / 80 - 95 °C

2: water; sodium hydroxide / tetrahydrofuran; methanol

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane

4: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tripotassium phosphate "n" hydrate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;

DOI:10.1016/j.bmcl.2011.05.115

Reference yield:

C15H19BrN4O2 (1033244-97-1) → C22H25ClN6O (1330075-39-2)

Guidance literature:

Multi-step reaction with 4 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; tripotassium phosphate "n" hydrate / 1,4-dioxane; water / 80 - 95 °C

2: water; sodium hydroxide / tetrahydrofuran; methanol

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane

4: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tripotassium phosphate "n" hydrate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;

DOI:10.1016/j.bmcl.2011.05.115

upstream raw materials:

methyl 2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

C₁₅H₁₉BrN₄O₂

C₂₃H₂₅ClN₄O₄

C₂₂H₂₃ClN₄O₄