tert-butyl (1-{4-[2-(4'-carbamoylbiphenyl-4-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutyl)carbamate

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Chemical Name:tert-butyl (1-{4-[2-(4'-carbamoylbiphenyl-4-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutyl)carbamate
CAS No.:1374263-67-8
Molecular Formula:C₄₂H₃₈N₆O₃
Molecular Weight:674.802
Hs Code.:

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Chemical Property of tert-butyl (1-{4-[2-(4'-carbamoylbiphenyl-4-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutyl)carbamate

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Technology Process of tert-butyl (1-{4-[2-(4'-carbamoylbiphenyl-4-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutyl)carbamate

There total 9 articles about tert-butyl (1-{4-[2-(4'-carbamoylbiphenyl-4-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 885-70-1
5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one

: 1374263-67-8
tert-butyl (1-{4-[2-(4'-carbamoylbiphenyl-4-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 10 steps

1.1: Lawessons reagent; pyridine / 18 h / 100 °C

2.1: 1 h / 95 °C

3.1: acetic acid / 13 h / 105 °C

4.1: N-Bromosuccinimide / tetrahydrofuran / 2 h / 0 - 20 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 15 h / Reflux

6.1: N-chloro-succinimide / chloroform / 22 h / Reflux

7.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium carbonate / water; N,N-dimethyl-formamide / 1 h / 160 °C / Microwave irradiation

8.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 49 h / 50 °C

9.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

9.2: 2.5 h / 0 - 20 °C

10.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 25 h / 100 °C

With Lawessons reagent; pyridine; potassium phosphate; N-chloro-succinimide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); hydrogen; sodium hydride; sodium hydrogencarbonate; sodium carbonate; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; toluene; 10.1: Suzuki Coupling;

Reference yield:

: 1204296-84-3
5,11-dihydro-6H-pyrido[2,3-b][1,4]benzo diazepine-6-thione

: 1374263-67-8
tert-butyl (1-{4-[2-(4'-carbamoylbiphenyl-4-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: 1 h / 95 °C

2.1: acetic acid / 13 h / 105 °C

3.1: N-Bromosuccinimide / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 15 h / Reflux

5.1: N-chloro-succinimide / chloroform / 22 h / Reflux

6.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium carbonate / water; N,N-dimethyl-formamide / 1 h / 160 °C / Microwave irradiation

7.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 49 h / 50 °C

8.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

8.2: 2.5 h / 0 - 20 °C

9.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 25 h / 100 °C

With potassium phosphate; N-chloro-succinimide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); hydrogen; sodium hydride; sodium hydrogencarbonate; sodium carbonate; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; toluene; 9.1: Suzuki Coupling;

Reference yield:

: 1374260-82-8
9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzo diazepine

: 1374263-67-8
tert-butyl (1-{4-[2-(4'-carbamoylbiphenyl-4-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 2 h / 0 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 15 h / Reflux

3.1: N-chloro-succinimide / chloroform / 22 h / Reflux

4.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium carbonate / water; N,N-dimethyl-formamide / 1 h / 160 °C / Microwave irradiation

5.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 49 h / 50 °C

6.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

6.2: 2.5 h / 0 - 20 °C

7.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 25 h / 100 °C

With potassium phosphate; N-chloro-succinimide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); hydrogen; sodium hydride; sodium hydrogencarbonate; sodium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; toluene; 7.1: Suzuki Coupling;