Technology Process of benzyl 3-(1,3-dioxolan-2-ylmethyl)-1,2,3,6-tetrahydropyridine-1-carboxylate
There total 1 articles about benzyl 3-(1,3-dioxolan-2-ylmethyl)-1,2,3,6-tetrahydropyridine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
Yield given. Multistep reaction;
1.) water, ethanol, 90 h, reflux., 2.) 4 h;
DOI:10.1248/cpb.31.1551
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 3.2 g / m-chloroperbenzoic acid / CH2Cl2 / 15 h / Ambient temperature
2: 46 percent / B2H6 / tetrahydrofuran / 1.) 1 h, 2.) 3 h, r.t.
3: 79 percent / pyridinium chlorochromate (PCC), NaOAc / CH2Cl2 / 5 h / Ambient temperature
4: 79 percent / NaH / benzene / 1 h / Ambient temperature
5: 78 percent / H2 / 5 percent Pd-C / ethanol / 2 h / 760 Torr / Ambient temperature
6: 99 percent / anhydrous K2CO3 / H2O; CHCl3 / 0.08 h / Ambient temperature
7: 260 mg / 1 percent HCl / acetone / 1.5 h / Heating
8: 97 percent / sodium borohydride / ethanol / 0.33 h
9: 79 percent / POCl3 / pyridine / 1 h / Ambient temperature
10: 124 mg / 1 N NaOH / methanol; H2O / 3 h / Ambient temperature
11: 78 mg / tert-BuOK / dimethylsulfoxide; benzene / 1 h / 70 °C
With
hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; potassium tert-butylate; hydrogen; sodium acetate; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; diborane; trichlorophosphate;
palladium on activated charcoal;
In
tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; chloroform; water; dimethyl sulfoxide; acetone; benzene;
DOI:10.1248/cpb.31.1551
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 3.2 g / m-chloroperbenzoic acid / CH2Cl2 / 15 h / Ambient temperature
2: 46 percent / B2H6 / tetrahydrofuran / 1.) 1 h, 2.) 3 h, r.t.
3: 79 percent / pyridinium chlorochromate (PCC), NaOAc / CH2Cl2 / 5 h / Ambient temperature
4: 79 percent / NaH / benzene / 1 h / Ambient temperature
5: 78 percent / H2 / 5 percent Pd-C / ethanol / 2 h / 760 Torr / Ambient temperature
6: 99 percent / anhydrous K2CO3 / H2O; CHCl3 / 0.08 h / Ambient temperature
7: 260 mg / 1 percent HCl / acetone / 1.5 h / Heating
With
hydrogenchloride; hydrogen; sodium acetate; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; diborane;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; chloroform; water; acetone; benzene;
DOI:10.1248/cpb.31.1551
