C₈H₄ClIN₂O

Base Information

• Chemical Name: C₈H₄ClIN₂O
• CAS No.: 1350438-42-4
• Molecular Formula: C₈H₄ClIN₂O
• Molecular Weight: 306.49
• Mol file: 1350438-42-4.mol

Synonyms:

Chemical Property of C₈H₄ClIN₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₈H₄ClIN₂O

There total 1 articles about C₈H₄ClIN₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diazomethyl-trimethyl-silane (18107-18-1) + 4-chloro-3-iodo-benzoyl chloride (42860-17-3) → C8H4ClIN2O (1350438-42-4)

Guidance literature:

In acetonitrile;

DOI:10.1016/j.bmcl.2011.09.016

Reference yield:

C8H4ClIN2O (1350438-42-4) → C16H9ClIN5O (1350438-48-0)

Guidance literature:

Multi-step reaction with 7 steps

1: hydrogen bromide; acetic acid

2: potassium tert-butylate / N,N-dimethyl-formamide / -50 - 20 °C

3: sodium acetate / 20 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / 50 °C

5: trichlorophosphate

6: hydrazine

With potassium tert-butylate; hydrogen bromide; sodium acetate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; hydrazine; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.09.016

Reference yield:

C8H4ClIN2O (1350438-42-4) → C23H12Cl2F3IN6O (1350438-49-1)

Guidance literature:

Multi-step reaction with 8 steps

1: hydrogen bromide; acetic acid

2: potassium tert-butylate / N,N-dimethyl-formamide / -50 - 20 °C

3: sodium acetate / 20 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / 50 °C

5: trichlorophosphate

6: hydrazine

8: potassium carbonate / N,N-dimethyl-formamide / 80 °C

With potassium tert-butylate; hydrogen bromide; sodium acetate; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; hydrazine; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.09.016

upstream raw materials:

diazomethyl-trimethyl-silane

4-chloro-3-iodo-benzoyl chloride

Downstream raw materials:

C₁₅H₈Cl₂IN₃

C₁₆H₉ClIN₅O

C₂₃H₁₂Cl₂F₃IN₆O

C₂₃H₁₂ClF₃I₂N₆O