Technology Process of SR-2364
There total 6 articles about SR-2364 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,6-dichloro-9-(3-fluorophenyl)-9H-purine; (4-nitro-3H-benzo[d]imidazol-2-yl)methanamine hydrochloride;
With
N-ethyl-N,N-diisopropylamine;
In
isopropyl alcohol;
at 90 ℃;
for 0.5h;
Microwave irradiation;
Inert atmosphere;
morpholine;
In
propan-1-ol;
at 130 ℃;
for 0.5h;
Microwave irradiation;
Inert atmosphere;
DOI:10.1016/j.bmcl.2013.05.075
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: copper diacetate; triethylamine / dichloromethane / 48 h / 20 °C / Molecular sieve; Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.5 h / 90 °C / Microwave irradiation; Inert atmosphere
2.2: 0.5 h / 130 °C / Microwave irradiation; Inert atmosphere
With
copper diacetate; triethylamine; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmcl.2013.05.075
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: acetic acid / 2 h / 70 °C / Inert atmosphere
2.1: hydrogenchloride / water; 1,4-dioxane / 23 °C / Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.5 h / 90 °C / Microwave irradiation; Inert atmosphere
3.2: 0.5 h / 130 °C / Microwave irradiation; Inert atmosphere
With
hydrogenchloride; acetic acid; N-ethyl-N,N-diisopropylamine;
In
1,4-dioxane; water; isopropyl alcohol;
DOI:10.1016/j.bmcl.2013.05.075
