isopropyl((2S)-1-(((3,4-dimethoxylphenyl)(4-bromophenyl)methyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

Base Information

• Chemical Name: isopropyl((2S)-1-(((3,4-dimethoxylphenyl)(4-bromophenyl)methyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate
• CAS No.: 1496524-39-0
• Molecular Formula: C₂₄H₃₁BrN₂O₅
• Molecular Weight: 507.425
• Mol file: 1496524-39-0.mol

Synonyms:

Chemical Property of isopropyl((2S)-1-(((3,4-dimethoxylphenyl)(4-bromophenyl)methyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of isopropyl((2S)-1-(((3,4-dimethoxylphenyl)(4-bromophenyl)methyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

There total 5 articles about isopropyl((2S)-1-(((3,4-dimethoxylphenyl)(4-bromophenyl)methyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3,4-dimethoxyphenyl)(4-bromophenyl)methylamine (1016509-04-8) + N-isopropoxycarbonyl-S-valine (140923-27-9) → isopropyl((2S)-1-(((3,4-dimethoxylphenyl)(4-bromophenyl)methyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate (1496524-39-0)

Guidance literature:

N-isopropoxycarbonyl-S-valine; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; for 1h;

(3,4-dimethoxyphenyl)(4-bromophenyl)methylamine; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1039/c4ob00744a

Reference yield:

(3,4-dimethoxyphenyl)(4-bromophenyl)methanone oxime (1620077-23-7) → isopropyl((2S)-1-(((3,4-dimethoxylphenyl)(4-bromophenyl)methyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate (1496524-39-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonium hydroxide; zinc; ammonium acetate / ethanol / 1 h / Reflux

2.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h / 0 °C

2.2: 2 h / 20 °C

With ammonium hydroxide; ammonium acetate; chloroformic acid ethyl ester; triethylamine; zinc; In tetrahydrofuran; ethanol;

DOI:10.1039/c4ob00744a

Reference yield:

(3,4-dimethoxyl phenyl)(4-bromophenyl)methanone (116412-90-9) → isopropyl((2S)-1-(((3,4-dimethoxylphenyl)(4-bromophenyl)methyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate (1496524-39-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide; hydroxylamine hydrochloride / ethanol / 6 h / Reflux

2.1: ammonium hydroxide; zinc; ammonium acetate / ethanol / 1 h / Reflux

3.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h / 0 °C

3.2: 2 h / 20 °C

With ammonium hydroxide; hydroxylamine hydrochloride; ammonium acetate; chloroformic acid ethyl ester; triethylamine; sodium hydroxide; zinc; In tetrahydrofuran; ethanol;

DOI:10.1039/c4ob00744a

upstream raw materials:

(3,4-dimethoxyphenyl)(4-bromophenyl)methanone oxime

(3,4-dimethoxyl phenyl)(4-bromophenyl)methanone

L-valine

(3,4-dimethoxyphenyl)(4-bromophenyl)methylamine

Refernces