2-pyrazolyletoricoxib

Base Information

Chemical Name:2-pyrazolyletoricoxib
CAS No.:1616667-36-7
Molecular Formula:C₂₁H₁₇ClN₄O₂S
Molecular Weight:424.911
Hs Code.:

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Suppliers and Price of 2-pyrazolyletoricoxib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-pyrazolyletoricoxib

Chemical Property:

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Technology Process of 2-pyrazolyletoricoxib

There total 2 articles about 2-pyrazolyletoricoxib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 288-13-1
NH-pyrazole

: 1616667-32-3
C₁₈H₁₄ClFN₂O₂S

: 1616667-36-7
2-pyrazolyletoricoxib

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 - 100 ℃; Inert atmosphere; Glovebox; Sealed tube;
DOI:10.1021/ja5049303

Reference yield:

: 202409-33-4
etoricoxib

: 1616667-36-7
2-pyrazolyletoricoxib

Guidance literature:: Multi-step reaction with 2 steps

1: silver(II) fluoride / acetonitrile / 2 h / 50 °C / Inert atmosphere; Glovebox; Sealed tube

2: sodium hydride / mineral oil; N,N-dimethyl-formamide / 20 - 100 °C / Inert atmosphere; Glovebox; Sealed tube

With silver(II) fluoride; sodium hydride; In N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1021/ja5049303