Technology Process of BETA-OXO-4-TERT-BUTYL-BENZENEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER
There total 2 articles about BETA-OXO-4-TERT-BUTYL-BENZENEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
acetic acid tert-butyl ester;
With
n-butyllithium; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
N-methoxy-N-methyl-4-(2-methyl-2-propanyl)benzamide;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
DOI:10.1021/acs.orglett.1c02744
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C
2.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / hexane; tetrahydrofuran / 0.5 h / -78 °C
2.2: 1 h / -78 °C
With
n-butyllithium; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/acs.orglett.1c02744
- Guidance literature:
-
With
C59H69N4O3(1+)*Br(1-); caesium carbonate;
In
water; toluene;
at 20 ℃;
Overall yield = 76 percent; Overall yield = 72 mg; enantioselective reaction;
DOI:10.1021/acs.orglett.1c02744
