3,6-Difluorocarbazole

Base Information

• Chemical Name: 3,6-Difluorocarbazole
• CAS No.: 1041143-98-9
• Molecular Formula: C₁₂H₇F₂N
• Molecular Weight: 203.191
• Mol file: 1041143-98-9.mol

Synonyms:

Chemical Property of 3,6-Difluorocarbazole

Chemical Property:

• Melting Point: 198.9-200.8 °C
• Boiling Point: 362.5±22.0 °C(Predicted)
• PKA: 15.96±0.30(Predicted)
• Density: 1.407±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

3,6-difluoro-9H-Carbazole 99.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,6-Difluorocarbazole

There total 8 articles about 3,6-Difluorocarbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(2-chloro-4-fluorophenyl)(4-fluorophenyl)amine (1041143-87-6) → 3,6-difluoro-9H-carbazole (1041143-98-9)

Guidance literature:

With palladium diacetate; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In N,N-dimethyl acetamide; for 18h; Reflux;

Reference yield: 71.0%

2,2'-bis(acetamido)-5,5'-difluorobiphenyl → 3,6-difluoro-9H-carbazole (1041143-98-9)

Guidance literature:

With phosphoric acid; In diethylene glycol; at 200 ℃; for 24h;

DOI:10.1055/s-0039-1690759

Reference yield:

1-Bromo-4-fluorobenzene (460-00-4) → 3,6-difluoro-9H-carbazole (1041143-98-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / toluene / 16 h / 100 °C / Inert atmosphere

2: tri tert-butylphosphoniumtetrafluoroborate; sodium t-butanolate; palladium diacetate / 1,4-dioxane / 20 h / 110 °C / Inert atmosphere; Sealed tube

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; toluene;

upstream raw materials:

(2-chloro-4-fluorophenyl)(4-fluorophenyl)amine

1-Bromo-4-fluorobenzene

2-chloro-4-fluoroaniline

2-bromo-4-fluoroaniline

Refernces

• 1、 -. "Fluorine-substituted bimolecular carbazole derivative as well as preparation method and application thereof". Paragraph 0078-0079; 0090-0097. . Retrieved 2020/07/08.
• 2、 Baek, Junghyun,Ban, Jaeyoung,Lim, Minkyung,Rhee, Hakjune,Shabbir, Saira. "Site-Specific Synthesis of Carbazole Derivatives through Aryl Homocoupling and Amination". . p. 917 - 927. Retrieved 2020/03/13.