Technology Process of (R)-4-Benzyloxymethyl-2-[(2R,6R,10S,14S)-15-(4-methoxy-benzyloxy)-2,6,10,14-tetramethyl-pentadecyl]-[1,3]dioxolane
There total 5 articles about (R)-4-Benzyloxymethyl-2-[(2R,6R,10S,14S)-15-(4-methoxy-benzyloxy)-2,6,10,14-tetramethyl-pentadecyl]-[1,3]dioxolane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: p-toluenesulfonic acid, MgSO4 / CH2Cl2 / 12 h / Ambient temperature
2: 5.09 g / tetrabutylammonium fluoride / tetrahydrofuran / 3.5 h / Ambient temperature
3: 1.) NaH / 1.) DMF, room temperature, 30 min, 2.) DMF, room temperature -> 40 deg C
With
tetrabutyl ammonium fluoride; sodium hydride; magnesium sulfate; toluene-4-sulfonic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo972328p
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) oxalyl chloride, DMSO, 2.) triethyamine / 1.) CH2Cl2, 2.) CH2Cl2
2: p-toluenesulfonic acid, MgSO4 / CH2Cl2 / 12 h / Ambient temperature
3: 5.09 g / tetrabutylammonium fluoride / tetrahydrofuran / 3.5 h / Ambient temperature
4: 1.) NaH / 1.) DMF, room temperature, 30 min, 2.) DMF, room temperature -> 40 deg C
With
oxalyl dichloride; tetrabutyl ammonium fluoride; sodium hydride; magnesium sulfate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo972328p
- Guidance literature:
-
Multi-step reaction with 3 steps
1: p-toluenesulfonic acid, MgSO4 / CH2Cl2 / 12 h / Ambient temperature
2: 5.09 g / tetrabutylammonium fluoride / tetrahydrofuran / 3.5 h / Ambient temperature
3: 1.) NaH / 1.) DMF, room temperature, 30 min, 2.) DMF, room temperature -> 40 deg C
With
tetrabutyl ammonium fluoride; sodium hydride; magnesium sulfate; toluene-4-sulfonic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo972328p
