epipodophyllic acid

Base Information

Chemical Name:epipodophyllic acid
CAS No.:4354-75-0
Molecular Formula:C₂₂H₂₄O₉
Molecular Weight:432.427
Hs Code.:

Synonyms:

Suppliers and Price of epipodophyllic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of epipodophyllic acid

Chemical Property:

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Technology Process of epipodophyllic acid

There total 59 articles about epipodophyllic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1256-91-3,55515-12-3,75171-58-3,78216-03-2,86334-69-2,116180-67-7,122871-76-5,127126-86-7
(+/-)-methyl epipodophyllate

: 477-67-8,477-68-9,518-48-9,1853-37-8,4354-75-0,79355-65-0,86334-72-7,100896-01-3,112068-24-3,113565-15-4,122871-78-7,122871-80-1,130981-13-4
epipicropodophyllic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; for 4h; Heating;
DOI:10.1021/jo00279a011

Reference yield: 58.0%

: 79289-93-3,86334-71-6
epipodophyllic acid 4,11-acetonide

: 477-67-8,477-68-9,518-48-9,1853-37-8,4354-75-0,79355-65-0,86334-72-7,100896-01-3,112068-24-3,113565-15-4,122871-78-7,122871-80-1,130981-13-4
epipodophyllic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 25 ℃; for 24h;
DOI:10.1021/jo00279a011

Reference yield:

: 1256-91-3,55515-12-3,75171-58-3,78216-03-2,86334-69-2,116180-67-7,122871-76-5,127126-86-7
(+/-)-methyl epipodophyllate

: 477-67-8,477-68-9,518-48-9,1853-37-8,4354-75-0,79355-65-0,86334-72-7,100896-01-3,112068-24-3,113565-15-4,122871-78-7,122871-80-1,130981-13-4
epipodophyllic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / p-toluenesulfonic acid

2: 82 percent / NaOH / H₂O; dioxane / 6 h / Heating

3: 45 percent / dilute acid / H₂O; dioxane / 24 h / Ambient temperature

With sodium hydroxide; dilute acid; toluene-4-sulfonic acid; In 1,4-dioxane; water;
DOI:10.1021/ja00410a038