(3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-4-methyl-2-<<(2S)-2-(3-oxohexahydro-3H-pyrrolo<1,2-c>imidazol-2-yl)-3-phenylpropionyl>amino>pentanoyl>amino>butyric acid isopropyl ester

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Chemical Name:(3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-4-methyl-2-<<(2S)-2-(3-oxohexahydro-3H-pyrrolo<1,2-c>imidazol-2-yl)-3-phenylpropionyl>amino>pentanoyl>amino>butyric acid isopropyl ester
CAS No.:137282-05-4
Molecular Formula:C₃₄H₅₂N₄O₆
Molecular Weight:612.81
Hs Code.:

(3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-4-methyl-2-<<(2S)-2-(3-oxohexahydro-3H-pyrrolo<1,2-c>imidazol-2-yl)-3-phenylpropionyl>amino>pentanoyl>amino>butyric acid isopropyl ester

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Chemical Property of (3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-4-methyl-2-<<(2S)-2-(3-oxohexahydro-3H-pyrrolo<1,2-c>imidazol-2-yl)-3-phenylpropionyl>amino>pentanoyl>amino>butyric acid isopropyl ester

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Technology Process of (3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-4-methyl-2-<<(2S)-2-(3-oxohexahydro-3H-pyrrolo<1,2-c>imidazol-2-yl)-3-phenylpropionyl>amino>pentanoyl>amino>butyric acid isopropyl ester

There total 6 articles about (3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-4-methyl-2-<<(2S)-2-(3-oxohexahydro-3H-pyrrolo<1,2-c>imidazol-2-yl)-3-phenylpropionyl>amino>pentanoyl>amino>butyric acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69610-41-9,117625-90-8
Boc-L-Pro-H

: 137282-05-4,139236-19-4,139236-26-3
(3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-4-methyl-2-<<(2S)-2-(3-oxohexahydro-3H-pyrrolo<1,2-c>imidazol-2-yl)-3-phenylpropionyl>amino>pentanoyl>amino>butyric acid isopropyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) N-methylmorpholine (NMM), 2.) NaCNBH₃ / 1.) MeOH, 5 min, 2.) MeOH, RT

2: trifluoroacetic acid / CH₂Cl₂ / Ambient temperature

3: tetrahydrofuran / Ambient temperature

4: 95 percent / 1 N aq. NaOH / methanol

5: 1.) 1-hydroxybenzotriazole (HOBt), 2.) 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate (CMC) / 1.) CH₂Cl₂, 0 deg C, 10 min, 2.) CH₂Cl₂, RT, overnight

With 4-methyl-morpholine; sodium hydroxide; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; sodium cyanoborohydride; benzotriazol-1-ol; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00083a005

Reference yield:

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 137282-05-4,139236-19-4,139236-26-3
(3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-4-methyl-2-<<(2S)-2-(3-oxohexahydro-3H-pyrrolo<1,2-c>imidazol-2-yl)-3-phenylpropionyl>amino>pentanoyl>amino>butyric acid isopropyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) N-methylmorpholine (NMM), 2.) NaCNBH₃ / 1.) MeOH, 5 min, 2.) MeOH, RT

2: trifluoroacetic acid / CH₂Cl₂ / Ambient temperature

3: tetrahydrofuran / Ambient temperature

4: 95 percent / 1 N aq. NaOH / methanol

5: 1.) 1-hydroxybenzotriazole (HOBt), 2.) 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate (CMC) / 1.) CH₂Cl₂, 0 deg C, 10 min, 2.) CH₂Cl₂, RT, overnight

With 4-methyl-morpholine; sodium hydroxide; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; sodium cyanoborohydride; benzotriazol-1-ol; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00083a005

Reference yield:

: 137282-33-8
(2S)-2-<<<(1S)-1-(methoxycarbonyl)-2-phenylethyl>amino>methyl>pyrrolidine

: 137282-05-4,139236-19-4,139236-26-3
(3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-4-methyl-2-<<(2S)-2-(3-oxohexahydro-3H-pyrrolo<1,2-c>imidazol-2-yl)-3-phenylpropionyl>amino>pentanoyl>amino>butyric acid isopropyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / Ambient temperature

2: 95 percent / 1 N aq. NaOH / methanol

3: 1.) 1-hydroxybenzotriazole (HOBt), 2.) 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate (CMC) / 1.) CH₂Cl₂, 0 deg C, 10 min, 2.) CH₂Cl₂, RT, overnight

With sodium hydroxide; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; benzotriazol-1-ol; In tetrahydrofuran; methanol;
DOI:10.1021/jm00083a005