19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-4,5α-epoxy-3,6-dimethoxy-17-methyl-6β,14-ethano-morphin-7-en-15-one (E)-oxime

Base Information

• Chemical Name: 19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-4,5α-epoxy-3,6-dimethoxy-17-methyl-6β,14-ethano-morphin-7-en-15-one (E)-oxime
• CAS No.: 36153-13-6
• Molecular Formula: C₂₉H₃₈N₂O₅
• Molecular Weight: 494.631
• Mol file: 36153-13-6.mol

Synonyms:

Chemical Property of 19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-4,5α-epoxy-3,6-dimethoxy-17-methyl-6β,14-ethano-morphin-7-en-15-one (E)-oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-4,5α-epoxy-3,6-dimethoxy-17-methyl-6β,14-ethano-morphin-7-en-15-one (E)-oxime

There total 3 articles about 19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-4,5α-epoxy-3,6-dimethoxy-17-methyl-6β,14-ethano-morphin-7-en-15-one (E)-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-1-cyclohexyl-1-(4,5α-epoxy-3,6-dimethoxy-17-methyl-15-nitroso-6α,14α-etheno-morphin-15-en-7α-yl)-ethanol (36153-16-9) → 19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-4,5α-epoxy-3,6-dimethoxy-17-methyl-6β,14-ethano-morphin-7-en-15-one (E)-oxime (36153-13-6,36153-14-7)

Guidance literature:

With sodium tetrahydroborate; In ethanol;

DOI:10.1039/P19720000875

Reference yield:

19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-4,5α-epoxy-3,6-dimethoxy-17-methyl-6β,14-ethano-morphina-7,16-dienium; chloride → 19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-4,5α-epoxy-3,6-dimethoxy-17-methyl-6β,14-ethano-morphin-7-en-15-one (E)-oxime (36153-13-6,36153-14-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-nitro-pentane / ethanol

2: liq. NH₃

3: NaBH₄ / ethanol

With sodium tetrahydroborate; ammonia; 1-nitropentane; In ethanol;

DOI:10.1039/P19720000875

Reference yield:

19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-4,5α-epoxy-15-hydroxyimino-3,6-dimethoxy-17-methyl-6β,14-ethano-morphina-7,16-dienium; chloride (36153-17-0) → 19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-4,5α-epoxy-3,6-dimethoxy-17-methyl-6β,14-ethano-morphin-7-en-15-one (E)-oxime (36153-13-6,36153-14-7)

Guidance literature:

Multi-step reaction with 2 steps

1: liq. NH₃

2: NaBH₄ / ethanol

With sodium tetrahydroborate; ammonia; In ethanol;

DOI:10.1039/P19720000875

upstream raw materials:

(R)-1-cyclohexyl-1-(4,5α-epoxy-3,6-dimethoxy-17-methyl-15-nitroso-6α,14α-etheno-morphin-15-en-7α-yl)-ethanol

19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-4,5α-epoxy-15-hydroxyimino-3,6-dimethoxy-17-methyl-6β,14-ethano-morphina-7,16-dienium; chloride

Downstream raw materials:

19anti-((R)-1-cyclohexyl-1-hydroxy-ethyl)-4,5α-epoxy-3,6-dimethoxy-17-methyl-6β,14-ethano-morphin-7-en-15-one (Z)-O-acetyl-oxime