Technology Process of 2-(3,4-Dimethoxy-benzyl)-succinic acid 1-cyanomethyl ester
There total 6 articles about 2-(3,4-Dimethoxy-benzyl)-succinic acid 1-cyanomethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 95 percent / H2 / Pd/C / methanol / 5 h
2: 80 percent / thionyl chloride / methanol / Heating
3: 85 percent / TEA / CH2Cl2 / Ambient temperature
4: CaCl2, NaOH, horse liver esterase / H2O / 3 h
With
sodium hydroxide; thionyl chloride; horse liver esterase; TEA; hydrogen; calcium chloride;
palladium on activated charcoal;
In
methanol; dichloromethane; water;
DOI:10.1016/S0040-4020(01)81084-X
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 84 percent / NaOMe
2: 95 percent / H2 / Pd/C / methanol / 5 h
3: 80 percent / thionyl chloride / methanol / Heating
4: 85 percent / TEA / CH2Cl2 / Ambient temperature
5: CaCl2, NaOH, horse liver esterase / H2O / 3 h
With
sodium hydroxide; thionyl chloride; horse liver esterase; TEA; hydrogen; sodium methylate; calcium chloride;
palladium on activated charcoal;
In
methanol; dichloromethane; water;
DOI:10.1016/S0040-4020(01)81084-X
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 84 percent / NaOMe
2: 95 percent / H2 / Pd/C / methanol / 5 h
3: 80 percent / thionyl chloride / methanol / Heating
4: 85 percent / TEA / CH2Cl2 / Ambient temperature
5: CaCl2, NaOH, horse liver esterase / H2O / 3 h
With
sodium hydroxide; thionyl chloride; horse liver esterase; TEA; hydrogen; sodium methylate; calcium chloride;
palladium on activated charcoal;
In
methanol; dichloromethane; water;
DOI:10.1016/S0040-4020(01)81084-X
