Isobutyric acid 4-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-3,5-dioxo-4,5,7,8-tetrahydro-3H,6H-1-thia-4,5a-diaza-acenaphthylen-8-yl ester

Base Information

Chemical Name:Isobutyric acid 4-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-3,5-dioxo-4,5,7,8-tetrahydro-3H,6H-1-thia-4,5a-diaza-acenaphthylen-8-yl ester
CAS No.:130475-39-7
Molecular Formula:C₂₆H₃₂N₄O₅S
Molecular Weight:512.63
Hs Code.:

Isobutyric acid 4-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-3,5-dioxo-4,5,7,8-tetrahydro-3H,6H-1-thia-4,5a-diaza-acenaphthylen-8-yl ester

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Chemical Property of Isobutyric acid 4-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-3,5-dioxo-4,5,7,8-tetrahydro-3H,6H-1-thia-4,5a-diaza-acenaphthylen-8-yl ester

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Technology Process of Isobutyric acid 4-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-3,5-dioxo-4,5,7,8-tetrahydro-3H,6H-1-thia-4,5a-diaza-acenaphthylen-8-yl ester

There total 7 articles about Isobutyric acid 4-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-3,5-dioxo-4,5,7,8-tetrahydro-3H,6H-1-thia-4,5a-diaza-acenaphthylen-8-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 130475-27-3
3,4,5,7,8,9-hexahydro-9-hydroxy-4-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<4,3,2-de>pyrido<1,2-c>pyrimidine-3,5-dione

: 79-30-1
isobutyryl chloride

: 130475-39-7
Isobutyric acid 4-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-3,5-dioxo-4,5,7,8-tetrahydro-3H,6H-1-thia-4,5a-diaza-acenaphthylen-8-yl ester

Guidance literature:: With dmap; In dichloromethane; Heating;

Reference yield:

: 39978-14-8
methyl 3-amino-4-thiophenecarboxylate hydrochloride

: 130475-39-7
Isobutyric acid 4-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-3,5-dioxo-4,5,7,8-tetrahydro-3H,6H-1-thia-4,5a-diaza-acenaphthylen-8-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 84 percent / aq. NaOH / CH₂Cl₂ / 2 h / Ambient temperature

2: 36 percent / AlMe₃ / toluene / 0 --> 100 degC

3: 75 percent / aq. C₆H₅CH₂N(CH₃)3OH / CHCl₃; methanol / 2 h / Heating

4: 28 percent / 50percent aq. NaOH / methanol / 2 h / Heating

5: 61 percent / P₂O₅, CH₃SO₃H (1:10 / 2 h / Ambient temperature

6: 58 percent / NaBH₄ / ethanol / 72 h / Ambient temperature

7: 68 percent / DMAP / CH₂Cl₂ / Heating

With dmap; sodium hydroxide; sodium tetrahydroborate; methanesulfonic acid; trimethylaluminum; phosphorus pentoxide; N-benzyl-trimethylammonium hydroxide; In methanol; ethanol; dichloromethane; chloroform; toluene;

Reference yield:

: 118252-16-7
ethyl (4-methoxycarbonyl)thiophene-3-carbamate

: 130475-39-7
Isobutyric acid 4-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-3,5-dioxo-4,5,7,8-tetrahydro-3H,6H-1-thia-4,5a-diaza-acenaphthylen-8-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 36 percent / AlMe₃ / toluene / 0 --> 100 degC

2: 75 percent / aq. C₆H₅CH₂N(CH₃)3OH / CHCl₃; methanol / 2 h / Heating

3: 28 percent / 50percent aq. NaOH / methanol / 2 h / Heating

4: 61 percent / P₂O₅, CH₃SO₃H (1:10 / 2 h / Ambient temperature

5: 58 percent / NaBH₄ / ethanol / 72 h / Ambient temperature

6: 68 percent / DMAP / CH₂Cl₂ / Heating

With dmap; sodium hydroxide; sodium tetrahydroborate; methanesulfonic acid; trimethylaluminum; phosphorus pentoxide; N-benzyl-trimethylammonium hydroxide; In methanol; ethanol; dichloromethane; chloroform; toluene;