(R)-2-{(R)-2-(Benzothiazol-2-yldisulfanyl)-3-[1-tert-butoxycarbonyl-meth-(Z)-ylidene]-4-oxo-azetidin-1-yl}-3-methyl-but-3-enoic acid benzhydryl ester

Base Information

Chemical Name:(R)-2-{(R)-2-(Benzothiazol-2-yldisulfanyl)-3-[1-tert-butoxycarbonyl-meth-(Z)-ylidene]-4-oxo-azetidin-1-yl}-3-methyl-but-3-enoic acid benzhydryl ester
CAS No.:229616-87-9
Molecular Formula:C₃₄H₃₂N₂O₅S₃
Molecular Weight:644.836
Hs Code.:

(R)-2-{(R)-2-(Benzothiazol-2-yldisulfanyl)-3-[1-tert-butoxycarbonyl-meth-(Z)-ylidene]-4-oxo-azetidin-1-yl}-3-methyl-but-3-enoic acid benzhydryl ester

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Chemical Property of (R)-2-{(R)-2-(Benzothiazol-2-yldisulfanyl)-3-[1-tert-butoxycarbonyl-meth-(Z)-ylidene]-4-oxo-azetidin-1-yl}-3-methyl-but-3-enoic acid benzhydryl ester

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Technology Process of (R)-2-{(R)-2-(Benzothiazol-2-yldisulfanyl)-3-[1-tert-butoxycarbonyl-meth-(Z)-ylidene]-4-oxo-azetidin-1-yl}-3-methyl-but-3-enoic acid benzhydryl ester

There total 6 articles about (R)-2-{(R)-2-(Benzothiazol-2-yldisulfanyl)-3-[1-tert-butoxycarbonyl-meth-(Z)-ylidene]-4-oxo-azetidin-1-yl}-3-methyl-but-3-enoic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 149-30-4,118090-09-8
2-Mercaptobenzothiazole

: 247115-05-5
(2S,4R,5R)-6-[1-tert-Butoxycarbonyl-meth-(Z)-ylidene]-3,3-dimethyl-4,7-dioxo-4λ⁴-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester

: 229616-87-9
(R)-2-{(R)-2-(Benzothiazol-2-yldisulfanyl)-3-[1-tert-butoxycarbonyl-meth-(Z)-ylidene]-4-oxo-azetidin-1-yl}-3-methyl-but-3-enoic acid benzhydryl ester

Guidance literature:: DOI:10.1016/j.bmcl.2003.09.078

Reference yield:

: 129792-01-4
benzhydryl 6-oxopenicillinate

: 229616-87-9
(R)-2-{(R)-2-(Benzothiazol-2-yldisulfanyl)-3-[1-tert-butoxycarbonyl-meth-(Z)-ylidene]-4-oxo-azetidin-1-yl}-3-methyl-but-3-enoic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 48 percent / m-CPBA

With 3-chloro-benzenecarboperoxoic acid;
DOI:10.1016/j.bmcl.2003.09.078

Reference yield:

: 167028-46-8
benzhydryl 6-(Z)-(1-tert-butoxycarbonylmethylene)penicillanate

: 229616-87-9
(R)-2-{(R)-2-(Benzothiazol-2-yldisulfanyl)-3-[1-tert-butoxycarbonyl-meth-(Z)-ylidene]-4-oxo-azetidin-1-yl}-3-methyl-but-3-enoic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 2 steps

1: MCPBA / CH₂Cl₂

2: toluene / Heating

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; toluene;
DOI:10.1016/S0960-894X(99)00325-X