Technology Process of (3S,4R)-3-(3-benzyloxypropyl-1,1-dimethyl)-2-methyl-4-trimehylsilylcyclopentanone
There total 3 articles about (3S,4R)-3-(3-benzyloxypropyl-1,1-dimethyl)-2-methyl-4-trimehylsilylcyclopentanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 78 percent / BF3*Et2O / toluene / 0.5 h / Ambient temperature
2: 1.) trimethylsilyltrifluoromethanesulfonate, triethylamine, 2.) Pd(AcO)2 / 1.) toluene, RT, 2.) acetonitrile, 3 h
3: 1.) CuBr*Me2S, chlorotrimethylsilane, 2.) KF / 1.) THF, HMPA, -78 deg C to 0 deg C, 10 h, 2.) methanol, 48 deg C, 2 h
With
palladium diacetate; potassium fluoride; chloro-trimethyl-silane; copper(I) bromide dimethylsulfide complex; trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; triethylamine;
In
toluene;
DOI:10.1016/S0040-4020(01)80784-5
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) trimethylsilyltrifluoromethanesulfonate, triethylamine, 2.) Pd(AcO)2 / 1.) toluene, RT, 2.) acetonitrile, 3 h
2: 1.) CuBr*Me2S, chlorotrimethylsilane, 2.) KF / 1.) THF, HMPA, -78 deg C to 0 deg C, 10 h, 2.) methanol, 48 deg C, 2 h
With
palladium diacetate; potassium fluoride; chloro-trimethyl-silane; copper(I) bromide dimethylsulfide complex; trimethylsilyl trifluoromethanesulfonate; triethylamine;
DOI:10.1016/S0040-4020(01)80784-5
- Guidance literature:
-
With
potassium fluoride; chloro-trimethyl-silane; copper(I) bromide dimethylsulfide complex;
Yield given. Multistep reaction;
1.) THF, HMPA, -78 deg C to 0 deg C, 10 h, 2.) methanol, 48 deg C, 2 h;
DOI:10.1016/S0040-4020(01)80784-5
