(+)-Dihydrexidine

Base Information

Chemical Name:(+)-Dihydrexidine
CAS No.:174691-84-0
Molecular Formula:C₁₇H₁₇NO₂
Molecular Weight:267.327
Hs Code.:
UNII:Q3PJ4B4D0X
Nikkaji Number:J577.233H
Wikipedia:Dihydrexidine
Pharos Ligand ID:PU42YFTV56AM
ChEMBL ID:CHEMBL25856

Synonyms:10,11-dihydroxyhexahydrobenzo(a)phenanthridine;DAR 0100A;DAR-0100A;DAR0100A;dihydrexidine

Suppliers and Price of (+)-Dihydrexidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+)-Dihydrexidine

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:267.125928785
Heavy Atom Count:20
Complexity:361

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC2=CC(=C(C=C2C3C1NCC4=CC=CC=C34)O)O
Isomeric SMILES:C1CC2=CC(=C(C=C2[C@@H]3[C@@H]1NCC4=CC=CC=C34)O)O
Recent ClinicalTrials:Infusion Laboratory: Protocol 4 (Dihydrexidine) - 13

Technology Process of (+)-Dihydrexidine

There total 16 articles about (+)-Dihydrexidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 406499-03-4
(6aR,12bS)-(+)-10,11-dimethoxy-5,6,6a,7,8,12b-hexahydrobenzo phenanthridine

: 174691-84-0,123039-93-0
dihydrexidine

Guidance literature:: With boron tribromide; In dichloromethane; Ambient temperature;
DOI:10.1021/jm00041a025

Reference yield:

: (6aR,12bS)-(+)-10,11-dimethoxy-5,6,6a,7,8,12b-hexahydrobenzo phenanthridine hydrochloride

: 174691-84-0,123039-93-0
dihydrexidine

Guidance literature:: With water; iodine(I) bromide; for 3h; Heating / reflux;

Reference yield:

: 132814-55-2
(((2-bromobenzyl)oxy)methanetriyl)tribenzene

: 174691-84-0,123039-93-0
dihydrexidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi; (1S,2S)-2-(2-methoxyphenoxy)-N,N-diMe-1,2-diphenylethanamine / toluene / 0.5 h / -78 °C

1.2: toluene / 0.5 h / -95 °C

1.3: NaHCO₃ / ethanol / 4 h / Heating

2.1: 77 mg / hydrochloric acid / methanol; tetrahydrofuran / 18 h / 20 °C

3.1: Zn; hydrochloric acid / ethanol / 0.17 h / 20 °C

4.1: hydrochloric acid / dioxane / 2.5 h / Heating

5.1: 23 mg / K₂CO₃ / 2-methyl-propan-2-ol / 1 h / Heating

6.1: 20 mg / BBr₃ / CH₂Cl₂; hexane / 12 h / -78 - 20 °C

With hydrogenchloride; n-butyllithium; boron tribromide; potassium carbonate; zinc; (1S,2S)-1-dimethylamino-2-(2-methoxyphenoxy)-1,2-diphenylethane; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; toluene; tert-butyl alcohol;
DOI:10.1016/j.tet.2004.03.039