(2R,3S,4R)-2-benzyl-3,4-dihydroxypyrrolidine hydrochloride

Base Information

Chemical Name:(2R,3S,4R)-2-benzyl-3,4-dihydroxypyrrolidine hydrochloride
CAS No.:99284-56-7
Molecular Formula:C₁₁H₁₅NO₂*ClH
Molecular Weight:229.707
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S,4R)-2-benzyl-3,4-dihydroxypyrrolidine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (2R,3S,4R)-2-benzyl-3,4-dihydroxypyrrolidine hydrochloride

There total 6 articles about (2R,3S,4R)-2-benzyl-3,4-dihydroxypyrrolidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87859-51-6
(2R,3S,4R)-2-benzyl-3,4-isopropylidenedioxypyrrolidine

: 99284-56-7
(2R,3S,4R)-2-benzyl-3,4-dihydroxypyrrolidine hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; water; for 3h; Heating;
DOI:10.1039/P19850001463

Reference yield:

: 100-44-7
benzyl chloride

: 99284-56-7
(2R,3S,4R)-2-benzyl-3,4-dihydroxypyrrolidine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Mg / 1.) THF; 2.) THF, room temperature, 1h

2: 76 percent / NaIO₄ / ethanol; H₂O / 0.5 h

3: 94 percent / hydroxylamine hydrochloride / pyridine / 3 h

4: pyridine / 1 h / 60 °C

5: 51 percent / lithium aluminium hydride / diethyl ether / 2 h

6: HCl / methanol; H₂O / 3 h / Heating

With pyridine; hydrogenchloride; sodium periodate; lithium aluminium tetrahydride; hydroxylamine hydrochloride; magnesium; In pyridine; methanol; diethyl ether; ethanol; water;
DOI:10.1039/P19850001463

Reference yield:

: 87796-30-3
5-deoxy-2,3-O-isopropylidene-5-phenyl-β-L-ribofuranose

: 99284-56-7
(2R,3S,4R)-2-benzyl-3,4-dihydroxypyrrolidine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / hydroxylamine hydrochloride / pyridine / 3 h

2: pyridine / 1 h / 60 °C

3: 51 percent / lithium aluminium hydride / diethyl ether / 2 h

4: HCl / methanol; H₂O / 3 h / Heating

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; hydroxylamine hydrochloride; In pyridine; methanol; diethyl ether; water;
DOI:10.1039/P19850001463