5-benzyloxycarbonyl-12,18-diethyl-7-methoxycarbonyl-2,2,8,13,17-pentamethylchlorin

Base Information

Chemical Name:5-benzyloxycarbonyl-12,18-diethyl-7-methoxycarbonyl-2,2,8,13,17-pentamethylchlorin
CAS No.:79264-63-4
Molecular Formula:C₃₉H₄₂N₄O₄
Molecular Weight:630.787
Hs Code.:

Synonyms:

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Chemical Property of 5-benzyloxycarbonyl-12,18-diethyl-7-methoxycarbonyl-2,2,8,13,17-pentamethylchlorin

Chemical Property:

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Technology Process of 5-benzyloxycarbonyl-12,18-diethyl-7-methoxycarbonyl-2,2,8,13,17-pentamethylchlorin

There total 26 articles about 5-benzyloxycarbonyl-12,18-diethyl-7-methoxycarbonyl-2,2,8,13,17-pentamethylchlorin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1830-54-2
3-oxopentanedioic acid dimethyl ester

: 79264-63-4
5-benzyloxycarbonyl-12,18-diethyl-7-methoxycarbonyl-2,2,8,13,17-pentamethylchlorin

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) sodium nitrite, 2.) zinc dust, sodium acetate / 1.) water, glacial acetic acid, 20 deg C, overnight, 2.) 70 - 80 deg C, 1 h

2: 94 percent / H₂ / palladium on charcoal / methanol; tetrahydrofuran / 5 h

3: 88 percent / aq. sodium hydrogen carbonate, iodine, potassium iodide / CHCl₃; H₂O / 0.25 h

4: H₂, sodium acetate / palladium on charcoal / methanol / 6 h

5: 68.4 percent / sulphuric acid / tetrahydrofuran / 24 h / 20 °C

6: 67.4 percent / toluene-p-sulphonic acid / CH₂Cl₂ / 0.17 h

7: trifluoroacetic acid / 0.17 h

8: methanol; trifluoroacetic acid / 0.75 h

9: 76.7 percent Turnov_. / CH₂Cl₂ / 1 h

10: 1.) hydrated copper(II) acetate, DBU, 2.) hydrogen sulphide / 1.) acetonitrile, reflux, 4 h, 2.) TFA, 22 h

With sulfuric acid; hydrogen sulfide; hydrogen; iodine; copper diacetate; sodium acetate; sodium hydrogencarbonate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide; zinc; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; trifluoroacetic acid;
DOI:10.1039/P19840002733

Reference yield:

: 95305-23-0
methyl 5-iodo-2-methoxycarbonylmethyl-4-methylpyrrole-3-carboxylate

: 79264-63-4
5-benzyloxycarbonyl-12,18-diethyl-7-methoxycarbonyl-2,2,8,13,17-pentamethylchlorin

Guidance literature:: Multi-step reaction with 7 steps

1: H₂, sodium acetate / palladium on charcoal / methanol / 6 h

2: 68.4 percent / sulphuric acid / tetrahydrofuran / 24 h / 20 °C

3: 67.4 percent / toluene-p-sulphonic acid / CH₂Cl₂ / 0.17 h

4: trifluoroacetic acid / 0.17 h

5: methanol; trifluoroacetic acid / 0.75 h

6: 76.7 percent Turnov_. / CH₂Cl₂ / 1 h

7: 1.) hydrated copper(II) acetate, DBU, 2.) hydrogen sulphide / 1.) acetonitrile, reflux, 4 h, 2.) TFA, 22 h

With sulfuric acid; hydrogen sulfide; hydrogen; copper diacetate; sodium acetate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; trifluoroacetic acid;
DOI:10.1039/P19840002733

Reference yield:

: 95305-22-9
4-methoxycarbonyl-5-methoxycarbonymethyl-3-methylpyrrole-2-carboxylic acid

: 79264-63-4
5-benzyloxycarbonyl-12,18-diethyl-7-methoxycarbonyl-2,2,8,13,17-pentamethylchlorin

Guidance literature:: Multi-step reaction with 8 steps

1: 88 percent / aq. sodium hydrogen carbonate, iodine, potassium iodide / CHCl₃; H₂O / 0.25 h

2: H₂, sodium acetate / palladium on charcoal / methanol / 6 h

3: 68.4 percent / sulphuric acid / tetrahydrofuran / 24 h / 20 °C

4: 67.4 percent / toluene-p-sulphonic acid / CH₂Cl₂ / 0.17 h

5: trifluoroacetic acid / 0.17 h

6: methanol; trifluoroacetic acid / 0.75 h

7: 76.7 percent Turnov_. / CH₂Cl₂ / 1 h

8: 1.) hydrated copper(II) acetate, DBU, 2.) hydrogen sulphide / 1.) acetonitrile, reflux, 4 h, 2.) TFA, 22 h

With sulfuric acid; hydrogen sulfide; hydrogen; iodine; copper diacetate; sodium acetate; sodium hydrogencarbonate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; trifluoroacetic acid;
DOI:10.1039/P19840002733