[(4R,6S)-6-((4R,6S)-6-Benzyl-2,2-dimethyl-[1,3]dioxan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-methanol

Base Information

Chemical Name:[(4R,6S)-6-((4R,6S)-6-Benzyl-2,2-dimethyl-[1,3]dioxan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-methanol
CAS No.:235098-88-1
Molecular Formula:C₂₁H₃₂O₅
Molecular Weight:364.482
Hs Code.:

Synonyms:

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Chemical Property of [(4R,6S)-6-((4R,6S)-6-Benzyl-2,2-dimethyl-[1,3]dioxan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-methanol

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Technology Process of [(4R,6S)-6-((4R,6S)-6-Benzyl-2,2-dimethyl-[1,3]dioxan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-methanol

There total 14 articles about [(4R,6S)-6-((4R,6S)-6-Benzyl-2,2-dimethyl-[1,3]dioxan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 235098-87-0
C₂₈H₃₈O₅

: 235098-88-1
[(4R,6S)-6-((4R,6S)-6-Benzyl-2,2-dimethyl-[1,3]dioxan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-methanol

Guidance literature:: With ammonia; calcium;
DOI:10.1016/S0040-4039(99)00645-0

Reference yield:

: 126178-07-2
(S)-(+)-1-(2,2-dimethyl-1,3-dioxan-5-ylidenamino)-2-methoxymethylpyrrolidine

: 235098-88-1
[(4R,6S)-6-((4R,6S)-6-Benzyl-2,2-dimethyl-[1,3]dioxan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-methanol

Guidance literature:: Multi-step reaction with 16 steps

1: t-BuLi / tetrahydrofuran / -105 °C

2: t-BuLi / tetrahydrofuran / -105 °C

3: aq. oxalic acid / diethyl ether

4: 94 percent / NaBH₄ / methanol / -78 °C

5: 93 percent / NaH / tetrahydrofuran

6: 91 percent / nBu₃SnH, AIBN / toluene / 100 °C

7: Ca/NH₃(l)

8: NEt₃, DMAP / CH₂Cl₂

9: 72 percent / LiI, NaHCO₃ / dimethylformamide / 80 °C

10: t-BuLi / tetrahydrofuran / -105 °C

11: t-BuLi / tetrahydrofuran / -105 °C

12: aq. oxalic acid / diethyl ether

13: NaBH₄ / methanol / -78 °C

14: NaH / tetrahydrofuran

15: nBu₃SnH, AIBN / toluene / 100 °C

16: 83 percent / Ca/NH₃(l)

With dmap; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); ammonia; tert.-butyl lithium; tri-n-butyl-tin hydride; oxalic acid; sodium hydride; sodium hydrogencarbonate; calcium; triethylamine; lithium iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(99)00645-0

Reference yield:

: 126178-04-9
[(S)-4-Benzyl-2,2-dimethyl-[1,3]dioxan-(5E)-ylidene]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine

: 235098-88-1
[(4R,6S)-6-((4R,6S)-6-Benzyl-2,2-dimethyl-[1,3]dioxan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-methanol

Guidance literature:: Multi-step reaction with 15 steps

1: t-BuLi / tetrahydrofuran / -105 °C

2: aq. oxalic acid / diethyl ether

3: 94 percent / NaBH₄ / methanol / -78 °C

4: 93 percent / NaH / tetrahydrofuran

5: 91 percent / nBu₃SnH, AIBN / toluene / 100 °C

6: Ca/NH₃(l)

7: NEt₃, DMAP / CH₂Cl₂

8: 72 percent / LiI, NaHCO₃ / dimethylformamide / 80 °C

9: t-BuLi / tetrahydrofuran / -105 °C

10: t-BuLi / tetrahydrofuran / -105 °C

11: aq. oxalic acid / diethyl ether

12: NaBH₄ / methanol / -78 °C

13: NaH / tetrahydrofuran

14: nBu₃SnH, AIBN / toluene / 100 °C

15: 83 percent / Ca/NH₃(l)

With dmap; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); ammonia; tert.-butyl lithium; tri-n-butyl-tin hydride; oxalic acid; sodium hydride; sodium hydrogencarbonate; calcium; triethylamine; lithium iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(99)00645-0