(S)-2-[(R)-2-[(S)-2-(3-Amino-propyl)-4-((S)-1-methylcarbamoyl-2-naphthalen-2-yl-ethyl)-3-oxo-piperazin-1-yl]-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(S)-2-[(R)-2-[(S)-2-(3-Amino-propyl)-4-((S)-1-methylcarbamoyl-2-naphthalen-2-yl-ethyl)-3-oxo-piperazin-1-yl]-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:910568-14-8
Molecular Formula:C₄₁H₅₃FN₆O₆
Molecular Weight:744.907
Hs Code.:

(S)-2-[(R)-2-[(S)-2-(3-Amino-propyl)-4-((S)-1-methylcarbamoyl-2-naphthalen-2-yl-ethyl)-3-oxo-piperazin-1-yl]-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (S)-2-[(R)-2-[(S)-2-(3-Amino-propyl)-4-((S)-1-methylcarbamoyl-2-naphthalen-2-yl-ethyl)-3-oxo-piperazin-1-yl]-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of (S)-2-[(R)-2-[(S)-2-(3-Amino-propyl)-4-((S)-1-methylcarbamoyl-2-naphthalen-2-yl-ethyl)-3-oxo-piperazin-1-yl]-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-piperidine-1-carboxylic acid tert-butyl ester

There total 8 articles about (S)-2-[(R)-2-[(S)-2-(3-Amino-propyl)-4-((S)-1-methylcarbamoyl-2-naphthalen-2-yl-ethyl)-3-oxo-piperazin-1-yl]-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 910568-08-0
(S)-2-[(R)-2-[(S)-2-(3-Benzyloxycarbonylamino-propyl)-4-((S)-1-methylcarbamoyl-2-naphthalen-2-yl-ethyl)-3-oxo-piperazin-1-yl]-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-piperidine-1-carboxylic acid tert-butyl ester

: 910568-14-8
(S)-2-[(R)-2-[(S)-2-(3-Amino-propyl)-4-((S)-1-methylcarbamoyl-2-naphthalen-2-yl-ethyl)-3-oxo-piperazin-1-yl]-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1016/j.bmcl.2006.05.087

Reference yield:

: 910567-88-3
{3-[(S)-4-((S)-1-Methylcarbamoyl-2-naphthalen-2-yl-ethyl)-3-oxo-piperazin-2-yl]-propyl}-carbamic acid benzyl ester

: 910568-14-8
(S)-2-[(R)-2-[(S)-2-(3-Amino-propyl)-4-((S)-1-methylcarbamoyl-2-naphthalen-2-yl-ethyl)-3-oxo-piperazin-1-yl]-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: EDCI; NMM; HOBt

2: CF₃CO₂H / CH₂Cl₂

3: EDCI; NMM; HOBt / dimethylformamide

4: H₂ / Pd/C / methanol

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.05.087

Reference yield:

: [(S)-4-((S)-1-Methylcarbamoyl-2-naphthalen-2-yl-ethylcarbamoyl)-4-(2-nitro-benzenesulfonylamino)-butyl]-carbamic acid benzyl ester

: 910568-14-8
(S)-2-[(R)-2-[(S)-2-(3-Amino-propyl)-4-((S)-1-methylcarbamoyl-2-naphthalen-2-yl-ethyl)-3-oxo-piperazin-1-yl]-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃ / dimethylformamide / 75 °C

2: 4-mercaptophenol; K₂CO₃ / acetonitrile

3: EDCI; NMM; HOBt

4: CF₃CO₂H / CH₂Cl₂

5: EDCI; NMM; HOBt / dimethylformamide

6: H₂ / Pd/C / methanol

With 4-methyl-morpholine; 4-sulfanylphenol; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2006.05.087