Technology Process of (2S,1'R,2'S,3'S)-N-[(R)-α-phenylglycinyl]-2-[2'-diethylphosphono-3'-phenylcyclopropyl]glycinonitrile
There total 7 articles about (2S,1'R,2'S,3'S)-N-[(R)-α-phenylglycinyl]-2-[2'-diethylphosphono-3'-phenylcyclopropyl]glycinonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 80 percent / m-chloroperbenzoic acid / CH2Cl2 / 48 h / 20 °C
2: 51 percent / lithium hexamethyldisilazide / tetrahydrofuran / -78 - -50 °C
3: 67 percent / pyridinium chlorochromate / CH2Cl2 / 12 h / 20 °C
4: methanol / 24 h / 20 °C
5: 0.17 g / methanol / 24 h / 20 °C
With
3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; dichloromethane;
5: Strecker reaction;
DOI:10.1016/j.bmc.2007.02.040
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 67 percent / pyridinium chlorochromate / CH2Cl2 / 12 h / 20 °C
2: methanol / 24 h / 20 °C
3: 0.17 g / methanol / 24 h / 20 °C
With
pyridinium chlorochromate;
In
methanol; dichloromethane;
3: Strecker reaction;
DOI:10.1016/j.bmc.2007.02.040
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 51 percent / lithium hexamethyldisilazide / tetrahydrofuran / -78 - -50 °C
2: 67 percent / pyridinium chlorochromate / CH2Cl2 / 12 h / 20 °C
3: methanol / 24 h / 20 °C
4: 0.17 g / methanol / 24 h / 20 °C
With
pyridinium chlorochromate; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; dichloromethane;
4: Strecker reaction;
DOI:10.1016/j.bmc.2007.02.040
